UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Fetal dural sinus thrombosis: A systematic review

Sacco, A; Pannu, D; Ushakov, F; Dyet, L; Pandya, P; (2021) Fetal dural sinus thrombosis: A systematic review. Prenatal Diagnosis , 41 (2) pp. 248-257. 10.1002/pd.5869.

[thumbnail of pd.5869.pdf] Text
pd.5869.pdf - Accepted version
Access restricted to UCL open access staff until 16 December 2021.

Download (3MB)

Abstract

Introduction: Fetal dural sinus thrombosis (DST) is a rare condition. Although numerous case reports exist, the findings appear heterogenous and providing accurate patient counselling remains challenging. Methods: A systematic literature review was conducted in accordance with PRISMA guidance. Results: Thirty‐one studies including 78 patients were included in this review. No association with maternal or neonatal coagulopathy, infection or trauma was found. The average gestational age at diagnosis was 25 weeks (range 17–34 weeks). Approximately half of foetuses affected were female (48.7%); one quarter were male (25.6%) and one quarter had no sex stated (25.6%). Termination of pregnancy was chosen in 25.6% of cases (20/78). In continuing pregnancies,10.3% (6/58) experienced a perinatal death. Antenatally, the majority of lesions either decreased in size (38.5%) or completely resolved (32.7%). The neonatal or childhood outcome was normal in 88.0% of survivors (44/50). The average age at follow up was 16.4 months, ranging from birth to 6 years. Conclusion: This review found that 10% of DST cases experience in‐utero or neonatal death. In survivors, the majority of cases reduce in size or completely resolve in pregnancy and 85% are reported to have a good outcome. However, further evidence is needed regarding long‐term neurocognitive sequelae.

Type: Article
Title: Fetal dural sinus thrombosis: A systematic review
Location: England
DOI: 10.1002/pd.5869
Publisher version: https://doi.org/10.1002/pd.5869
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health > Maternal and Fetal Medicine
URI: https://discovery.ucl.ac.uk/id/eprint/10117023
Downloads since deposit
1Download
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item