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Preclinical evaluation of a thin-strut bioresorbable scaffold (ArterioSorb)

Katagiri, Y; Torii, R; Takahashi, K; Tenekecioglu, E; Asano, T; Chichareon, P; Tomaniak, M; ... Onuma, Y; + view all (2020) Preclinical evaluation of a thin-strut bioresorbable scaffold (ArterioSorb). EuroIntervention , 16 (2) e141-e146. 10.4244/EIJ-D-18-01190.

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Abstract

Aims: The aim of this study was to assess the acute performance of the 95 µm ArterioSorb oriented poly L-lactic acid (PLLA) scaffold in comparison with the XIENCE metallic drug-eluting stent (DES) in porcine coronary arteries. Methods and results: In 15 non-atherosclerotic Yucatan mini pigs, the ArterioSorb (3.0/14 mm) and XIENCE (3.0/15 mm) were implanted in 25 and 15 vessels, respectively. Acute performance was evaluated by using quantitative coronary angiography (QCA) and optical coherence tomography (OCT). Following three-dimensional reconstruction of the coronary arteries, endothelial shear stress (ESS) was quantified using non-Newtonian steady-flow simulation. Acute recoil measured by QCA was comparable in the two arms. Post-procedural flow and scaffold/stent area by OCT did not differ between the two devices. ESS post procedure was comparable between ArterioSorb and XIENCE (2.21±1.97 vs 2.25±1.71 Pa, p=0.314). Conclusions: Acute recoil, luminal dimensions and ESS in the ArterioSorb oriented PLLA scaffold with thin struts of 95 µm were comparable to those in the XIENCE metallic DES.

Type: Article
Title: Preclinical evaluation of a thin-strut bioresorbable scaffold (ArterioSorb)
DOI: 10.4244/EIJ-D-18-01190
Publisher version: https://doi.org/10.4244/EIJ-D-18-01190
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Mechanical Engineering
URI: https://discovery.ucl.ac.uk/id/eprint/10116772
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