UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

MRI susceptibility mapping shows decreased venous oxygen saturation in sickle cell anaemia

Murdoch, R; Stotesbury, H; Kawadler, J; Kirkham, F; Shmueli, K; (2019) MRI susceptibility mapping shows decreased venous oxygen saturation in sickle cell anaemia. In: Proceedings of the ISMRM 27th Annual Meeting & Exhibition. SMRT 28th Annual Meeting. (pp. pp. 1-3). International Society for Magnetic Resonance in Medicine (ISMRM) Green open access

[img]
Preview
Text
Murdoch_ISMRM_2019_Oxygen.pdf - Published version

Download (405kB) | Preview

Abstract

Ischemic stroke is a common and severe occurrence in Sickle Cell Anaemia (SCA) but no accurate screening measures currently exist for adults. Changes in venous oxygen saturation (Y_{v}) have been suggested as a potential biomarker but measuring Y_{v} in vivo is challenging. This work explores the potential of MRI susceptibility mapping to measure Y_{v} in SCA subjects. Susceptibility-mapping-based measures of Y_{v} were compared between 25 SCA subjects and 15 healthy controls. Significantly lower Y_{v} was measured in the superior sagittal sinus in the SCA group compared to healthy controls, showing that QSM is sensitive to changes in Y_{v} in SCA.

Type: Proceedings paper
Title: MRI susceptibility mapping shows decreased venous oxygen saturation in sickle cell anaemia
Event: ISMRM 27th Annual Meeting & Exhibition. SMRT 28th Annual Meeting
Location: Montreal (QC), Canada
Dates: 11th-16th May 2019
Open access status: An open access version is available from UCL Discovery
Publisher version: https://index.mirasmart.com/ISMRM2019/PDFfiles/402...
Language: English
Additional information: This version is the version of record. For information on re-use, please refer to the publisher's terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Neurosciences Dept
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng
URI: https://discovery.ucl.ac.uk/id/eprint/10116375
Downloads since deposit
12Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item