Murdoch, R;
Stotesbury, H;
Kawadler, J;
Kirkham, F;
Shmueli, K;
(2019)
MRI susceptibility mapping shows decreased venous oxygen saturation in sickle cell anaemia.
In:
Proceedings of the ISMRM 27th Annual Meeting & Exhibition. SMRT 28th Annual Meeting.
(pp. pp. 1-3).
International Society for Magnetic Resonance in Medicine (ISMRM)
Preview |
Text
Murdoch_ISMRM_2019_Oxygen.pdf - Published Version Download (405kB) | Preview |
Abstract
Ischemic stroke is a common and severe occurrence in Sickle Cell Anaemia (SCA) but no accurate screening measures currently exist for adults. Changes in venous oxygen saturation (Y_{v}) have been suggested as a potential biomarker but measuring Y_{v} in vivo is challenging. This work explores the potential of MRI susceptibility mapping to measure Y_{v} in SCA subjects. Susceptibility-mapping-based measures of Y_{v} were compared between 25 SCA subjects and 15 healthy controls. Significantly lower Y_{v} was measured in the superior sagittal sinus in the SCA group compared to healthy controls, showing that QSM is sensitive to changes in Y_{v} in SCA.
Archive Staff Only
 |
View Item |
