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MRI susceptibility mapping suggests elevated brain iron in sickle cell anaemia

Murdoch, R; Kawadler, J; Kirkham, F; Shmueli, K; (2019) MRI susceptibility mapping suggests elevated brain iron in sickle cell anaemia. In: Proceedings of the ISMRM 27th Annual Meeting & Exhibition. SMRT 28th Annual Meeting. (pp. pp. 1-3). International Society for Magnetic Resonance in Medicine (ISMRM) Green open access

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Abstract

Sickle Cell Anaemia (SCA) is a genetic condition characterized by haemolytic anaemia, cerebral vasculopathy and cognitive impairment. The effect of SCA on brain iron concentrations has not been extensively studied. Brain iron is important in cognitive function and iron overload may accelerate neurodegeneration. Here, susceptibility mapping (QSM) was used to compare brain tissue susceptibility values in 86 SCA patients and 25 healthy controls. Elevated susceptibility was found in the red nucleus of the SCA group versus controls, suggesting increased iron accumulation. In SCA subjects there was no significant effect of silent cerebral infarcts or anaemia severity on brain susceptibility values.

Type: Proceedings paper
Title: MRI susceptibility mapping suggests elevated brain iron in sickle cell anaemia
Event: ISMRM 27th Annual Meeting & Exhibition. SMRT 28th Annual Meeting
Location: Montreal (QC), Canada
Dates: 11th-16th May 2019
Open access status: An open access version is available from UCL Discovery
Publisher version: https://index.mirasmart.com/ISMRM2019/PDFfiles/506...
Language: English
Additional information: This version is the version of record. For information on re-use, please refer to the publisher's terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Neurosciences Dept
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng
URI: https://discovery.ucl.ac.uk/id/eprint/10116374
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