Magdalinou, Nadia Konstantina;
(2020)
Diagnostics in Neurodegenerative Parkinsonism.
Doctoral thesis (Ph.D), UCL (University College London).
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Abstract
The atypical Parkinsonian syndromes are a heterogeneous group of neurodegenerative disorders that show significant clinical and pathological overlap. Their differential diagnosis and distinction from Parkinson’s disease still depends primarily on clinical acumen, although neuro-‐imaging may be useful in a small number of cases. The development of a reliable diagnostic biomarker could significantly improve clinical practice. In this thesis, the diagnostic potential of targeted cerebrospinal fluid markers will be assessed. An unbiased approach, using proteomics, will also be explored to identify new and sometimes unexpected potential candidate biomarkers for further investigation. In addition, the diagnostic value of cerebrospinal fluid markers combined with neuroimaging techniques will be evaluated. Finally, specific linguistic processes and the effect of dopaminergic modulation will be tested in parkinsonian syndromes; deficiencies exposed by neuropsychometric testing will be correlated with specific areas of cortical atrophy.
| Type: | Thesis (Doctoral) |
|---|---|
| Qualification: | Ph.D |
| Title: | Diagnostics in Neurodegenerative Parkinsonism |
| Event: | UCL (University College London) |
| Open access status: | An open access version is available from UCL Discovery |
| Language: | English |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10116026 |
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