UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Earlymortality after implantable cardioverter defibrillator: Incidence and associated factors

Garcia, R; Boveda, S; Defaye, P; Sadoul, N; Narayanan, K; Perier, M-C; Klug, D; ... Algalarrondo, V; + view all (2020) Earlymortality after implantable cardioverter defibrillator: Incidence and associated factors. International Journal of Cardiology , 301 pp. 114-118. 10.1016/j.ijcard.2019.09.033. Green open access

[thumbnail of Bebiano Da Providencia E Costa_Earlymortality after implantable cardioverter defibrillator- Incidence and associated factors_AAM.pdf]
Preview
Text
Bebiano Da Providencia E Costa_Earlymortality after implantable cardioverter defibrillator- Incidence and associated factors_AAM.pdf - Accepted Version

Download (184kB) | Preview

Abstract

BACKGROUND: According to guidelines, implantable cardioverter defibrillator (ICD) candidates must have a “reasonable expectation of survival with a good functional status >1 year”. Identifying risk for early mortality in ICD candidates could be challenging. We aimed to identify factors associated with a ≤1-year survival among patients implanted with ICDs. METHODS: The DAI-PP program was a multicenter, observational French study that included all patients who received a primary prevention ICD in the 2002–2012 period. Characteristics of patients who survived ≤1 year following the implantation were compared with those who survived >1 year, and predictors of early death determined. RESULTS: Out of the 5539 enrolled patients, survival status at 1 year was known for a total of 5,457, and overall 230 (4.2%) survived ≤1 year. Causes of death were similar in the two groups. Patients with ≤1-year survival had lower rates of appropriate (14 vs. 23%; P = 0.004) and inappropriate ICD therapies (2 vs. 7%; P = 0.009) than patients who lived >1 year after ICD implantation. In multivariate analysis, older age, higher NYHA class (≥III), and atrial fibrillation were significantly associated with ≤1-year survival. Presence of all 3 risk factors was associated with a cumulative 22.63% risk of death within 1 year after implantation. CONCLUSIONS: This is the largest study determining the factors predicting early mortality after ICD implantation. Patients dying within the first year had low ICD therapy rates. A combination of clinical factors could potentially identify patients at risk for early mortality to help improve selection of ICD candidates.

Type: Article
Title: Earlymortality after implantable cardioverter defibrillator: Incidence and associated factors
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.ijcard.2019.09.033
Publisher version: https://doi.org/10.1016/j.ijcard.2019.09.033
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions.
Keywords: Implantable cardioverter defibrillator, Guideline, Mortality, Sudden cardiac death, Heart failure, Prevention
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Health Informatics
URI: https://discovery.ucl.ac.uk/id/eprint/10115530
Downloads since deposit
172Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item