Chen, L-J;
Hamer, M;
Lai, Y-J;
Huang, B-H;
Ku, P-W;
Stamatakis, E;
(2021)
Can physical activity eliminate the mortality risk associated with poor sleep? A 15-year follow-up of 341,248 MJ Cohort participant.
Journal of Sport and Health Science
10.1016/j.jshs.2021.03.001.
(In press).
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Abstract
Background: This study examined the joint associations of sleep patterns and physical activity (PA) with all-cause, cardiovascular disease (CVD), and cancer mortality. Methods: A total of 341,248 adults (mean age = 39.7 years; men: 48.3%) were included in the study, with a 15-year follow-up. Participants reported sleep duration and disturbances (difficulty falling asleep, easily awakened, or use of sleeping medication). PA was classified into 4 levels: <7.5, 7.5–14.9, 15–29.9, and ≥30 metabolic equivalent hours per week (MET-h/week). To understand the joint associations of sleep patterns and PA with mortality, Cox proportional hazard models were conducted, with exposure variables combining sleep duration/disturbances and PA. Results: Compared with the reference group (sleeping 6–8 h/day), individuals who slept >8 h/day had higher risk for all-cause mortality (hazard ratios (HR) = 1.31, 95% confidence interval (95%CI): 1.25–1.37), CVD mortality (HR = 1.30, 95%CI: 1.17–1.45), and cancer mortality (HR = 1.13, 95%CI: 1.04–1.22). Short sleep duration was not associated with mortality risk. Increased risk of all-cause and CVD mortality was found in participants who had difficulty falling asleep (HR = 1.12, 95%CI: 1.07–1.18; HR = 1.16, 95%CI: 1.04–1.30, respectively), and used sleeping medication (HR = 1.26, 95%CI: 1.16–1.37; HR = 1.34, 95%CI: 1.10–1.62, respectively) compared with those who slept well. Long sleep duration and sleep disturbances were not associated with risk of all-cause and CVD mortality among individuals achieving a PA level of ≥15 MET-h/week, and in particular among those achieving ≥30 MET-h/week. Conclusions: Long sleep duration, difficulty falling asleep, and use of sleeping medication were related to a higher risk of death. Being physically active at a moderate intensity for 25–65 min/day eliminated these detrimental associations.
| Type: | Article |
|---|---|
| Title: | Can physical activity eliminate the mortality risk associated with poor sleep? A 15-year follow-up of 341,248 MJ Cohort participant |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.jshs.2021.03.001 |
| Publisher version: | https://doi.org/10.1016/j.jshs.2021.03.001 |
| Language: | English |
| Additional information: | This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| Keywords: | Exercise, Heart disease, Inactivity, Insomnia, Sleep disorders |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10115335 |
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