Wen, T;
Duncan, J;
Mitchell, DJ;
(2020)
Hierarchical Representation of Multistep Tasks in Multiple-Demand and Default Mode Networks.
Journal of Neuroscience
, 40
(40)
pp. 7724-7738.
10.1523/JNEUROSCI.0594-20.2020.
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Abstract
Task episodes consist of sequences of steps that are performed to achieve a goal. We used fMRI to examine neural representation of task identity, component items, and sequential position, focusing on two major cortical systems—the multipledemand (MD) and default mode networks (DMN). Human participants (20 males, 22 females) learned six tasks each consisting of four steps. Inside the scanner, participants were cued which task to perform and then sequentially identified the target item of each step in the correct order. Univariate time course analyses indicated that intra-episode progress was tracked by a tonically increasing global response, plus an increasing phasic step response specific to MD regions. Inter-episode boundaries evoked a widespread response at episode onset, plus a marked offset response specific to DMN regions. Representational similarity analysis (RSA) was used to examine representation of task identity and component steps. Both networks represented the content and position of individual steps, however the DMN preferentially represented task identity while the MD network preferentially represented step-level information. Thus, although both MD and DMN networks are sensitive to step-level and episode-level information in the context of hierarchical task performance, they exhibit dissociable profiles in terms of both temporal dynamics and representational content. The results suggest collaboration of multiple brain regions in control of multistep behavior, with MD regions particularly involved in processing the detail of individual steps, and DMN adding representation of broad task context.
| Type: | Article |
|---|---|
| Title: | Hierarchical Representation of Multistep Tasks in Multiple-Demand and Default Mode Networks |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1523/JNEUROSCI.0594-20.2020 |
| Publisher version: | https://doi.org/10.1523/JNEUROSCI.0594-20.2020 |
| Language: | English |
| Additional information: | This is an open-access article distributed under the terms of the Creative Commons Attribution License Creative Commons Attribution 4.0 International, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. https://creativecommons.org/licenses/by/4.0/ |
| Keywords: | default mode network; fMRI; hierarchy; multiple-demand network; representational similarity analysis; task episodes |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Experimental Epilepsy |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10114652 |
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