UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Continuous Single-Phase Synthesis of [Au₂₅(Cys)₁₈] Nanoclusters and their Photobactericidal Enhancement

Hwang, GB; Wu, G; Shin, J; Panariello, L; Sebastian, V; Karu, K; Allan, E; ... Parkin, IP; + view all (2020) Continuous Single-Phase Synthesis of [Au₂₅(Cys)₁₈] Nanoclusters and their Photobactericidal Enhancement. ACS Applied Materials & Interfaces , 12 (43) pp. 49021-49029. 10.1021/acsami.0c07691. Green open access

[thumbnail of Gavriilidis_Final revised manuscript.pdf]
Preview
Text
Gavriilidis_Final revised manuscript.pdf - Accepted Version

Download (1MB) | Preview

Abstract

Thiolate–gold nanoclusters have various applications. However, most of the synthesis methods require prolonged synthesis times from several hours to days. In the present study, we report a rapid synthesis method for [Au25(Cys)18] nanoclusters and their application for photobactericidal enhancement. For [Au25(Cys)18] synthesis, we employed a tube-in-tube membrane reactor using CO as a reducing agent at elevated temperatures. This approach allows continuous generation of high-quality [Au25(Cys)18] within 3 min. Photobactericidal tests against Staphylococcus aureus showed that crystal violet-treated polymer did not have photobactericidal activity, but addition of [Au25(Cys)18] in the treated polymer demonstrated a potent photobactericidal activity at a low white light flux, resulting in >4.29 log reduction in viable bacteria numbers. Steady-state and time-resolved photoluminescence spectroscopies demonstrated that after light irradiation, photoexcited electrons in crystal violet flowed to [Au25(Cys)18] in the silicone, suggesting that redox reaction from [Au25(Cys)18] enhanced the photobactericidal activity. Stability tests revealed that leaching of crystal violet and [Au25(Cys)18] from the treated silicone was negligible and cyclic testing showed that the silicone maintained a strong photobactericidal activity after repeated use.

Type: Article
Title: Continuous Single-Phase Synthesis of [Au₂₅(Cys)₁₈] Nanoclusters and their Photobactericidal Enhancement
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1021/acsami.0c07691
Publisher version: https://doi.org/10.1021/acsami.0c07691
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Staphylococcus aureus, [Au25(Cys)18], bactericidal activity, continuous flow, crystal violet, gold nanocluster, membrane reactor, photocatalyst
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute > Microbial Diseases
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Chemical Engineering
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Chemistry
URI: https://discovery.ucl.ac.uk/id/eprint/10113842
Downloads since deposit
154Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item