UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Toward quantitative limited-angle ultrasound reflection tomography to inform abdominal HIFU treatment planning

Heanes, Daniel; (2020) Toward quantitative limited-angle ultrasound reflection tomography to inform abdominal HIFU treatment planning. Masters thesis (M.Phil), UCL (University College London). Green open access

[thumbnail of Heanes_Thesis.pdf]

Download (5MB) | Preview


High-Intensity Focused Ultrasound (HIFU) is a treatment modality for solid cancers of the liver and pancreas which is non-invasive and free from many of the side-effects of radiotherapy and chemotherapy. The safety and efficacy of abdominal HIFU treatment is dependent on the ability to bring the therapeutic sound waves to a small focal ”lesion” of known and controllable location within the patient anatomy. To achieve this, pre-treatment planning typically includes a numerical simulation of the therapeutic ultrasound beam, in which anatomical compartment locations are derived from computed tomography or magnetic resonance images. In such planning simulations, acoustic properties such as density and speed-of-sound are assumed for the relevant tissues which are rarely, if ever, determined specifically for the patient. These properties are known to vary between patients and disease states of tissues, and to influence the intensity and location of the HIFU lesion. The subject of this thesis is the problem of non-invasive patient-specific measurement of acoustic tissue properties. The appropriate method, also, of establishing spatial correspondence between physical ultrasound transducers and modeled (imaged) anatomy via multimodal image reg-istration is also investigated; this is of relevance both to acoustic tissue property estimation and to the guidance of HIFU delivery itself. First, the principle of a method is demonstrated with which acoustic properties can be recovered for several tissues simultaneously using reflection ultrasound, given accurate knowledge of the physical locations of tissue compartments. Second, the method is developed to allow for some inaccuracy in this knowledge commensurate with the inaccuracy typical in abdominal multimodal image registration. Third, several current multimodal image registration techniques, and two novel modifications, are compared for accuracy and robustness. In conclusion, relevant acoustic tissue properties can, in principle, be estimated using reflected ultrasound data that could be acquired using diagnostic imaging transducers in a clinical setting.

Type: Thesis (Masters)
Qualification: M.Phil
Title: Toward quantitative limited-angle ultrasound reflection tomography to inform abdominal HIFU treatment planning
Event: UCL (University College London)
Open access status: An open access version is available from UCL Discovery
Language: English
Additional information: Copyright © The Author 2020. Original content in this thesis is licensed under the terms of the Creative Commons Attribution 4.0 International (CC BY 4.0) Licence (https://creativecommons.org/licenses/by/4.0/). Any third-party copyright material present remains the property of its respective owner(s) and is licensed under its existing terms. Access may initially be restricted at the author’s request.
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
URI: https://discovery.ucl.ac.uk/id/eprint/10113784
Downloads since deposit
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item