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Sub-second Dopamine and Serotonin Signaling in Human Striatum during Perceptual Decision-Making

Bang, D; Kishida, KT; Lohrenz, T; White, JP; Laxton, AW; Tatter, SB; Fleming, SM; (2020) Sub-second Dopamine and Serotonin Signaling in Human Striatum during Perceptual Decision-Making. Neuron 10.1016/j.neuron.2020.09.015. (In press). Green open access

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Abstract

Recent animal research indicates that dopamine and serotonin, neuromodulators traditionally linked to appetitive and aversive processes, are also involved in sensory inference and decisions based on such inference. We tested this hypothesis in humans by monitoring sub-second striatal dopamine and serotonin signaling during a visual motion discrimination task that separates sensory uncertainty from decision difficulty in a factorial design. Caudate nucleus recordings (n = 4) revealed multi-scale encoding: in three participants, serotonin tracked sensory uncertainty, and, in one participant, both dopamine and serotonin tracked deviations from expected trial transitions within our factorial design. Putamen recordings (n = 1) supported a cognition-action separation between caudate nucleus and putamen—a striatal sub-division unique to primates—with both dopamine and serotonin tracking decision times. These first-of-their-kind observations in the human brain reveal a role for sub-second dopamine and serotonin signaling in non-reward-based aspects of cognition and action.

Type: Article
Title: Sub-second Dopamine and Serotonin Signaling in Human Striatum during Perceptual Decision-Making
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.neuron.2020.09.015
Publisher version: https://doi.org/10.1016/j.neuron.2020.09.015
Language: English
Additional information: Copyright © 2020 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Keywords: dopamine, seroton, inneuromodulation, perception, decision-making, cognition, action, human, striatum, fast scan cyclic voltammetry
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Experimental Psychology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Imaging Neuroscience
URI: https://discovery.ucl.ac.uk/id/eprint/10112150
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