Kibble, Joe;
(2020)
Investigating the Anti-Depressant Effects of Sub-Anaesthetic Ketamine in People with Chronic Pain.
Doctoral thesis (D.Clin.Psy), UCL (University College London).
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Abstract
Part one of this thesis is a meta-analysis examining the evidence for an association between ketamine’s antidepressant and dissociative effects. 12 studies were included in this analysis. Correlations between change scores on dissociation and depression were used to calculate the effect sizes. Overall there was a significant, albeit small, negative correlation between change scores (r = -0.16). Results indicate that increased dissociation is associated with reduced depression in ketamine treatment, although the effect is small Part two of the thesis describes an empirical study that aimed to explore the acute effects of sub-anaesthetic ketamine in a chronic pain population on mood, subjective experience, and pain. Measurements were taken at baseline, mid-point, post-infusion and follow-up. Ketamine resulted in lower pain scores during the infusion, however, at one-week follow-up some of the pain scores returned to baseline for ketamine, whereas for lidocaine these reductions were sustained. Ketamine did not show superior antidepressant effects compared to lidocaine. Whilst ketamine did produce greater rewarding experiences, it did not appear to lead to greater desire for taking more of the drug in this setting. Part three of the thesis presents a critical appraisal of the research. It reflects on the various factors that influenced my approach to the research and my experiences of conducting research in a clinical setting. This thesis is a joint project with Georgia Halls, who investigated the effects of ketamine on cognitive function in the same sample. Additionally, this is a continuation of a previous project started by two UCL Doctorate in Clinical Psychology trainees, Catherine Trotman and Matt Knox, in 2016.
| Type: | Thesis (Doctoral) |
|---|---|
| Qualification: | D.Clin.Psy |
| Title: | Investigating the Anti-Depressant Effects of Sub-Anaesthetic Ketamine in People with Chronic Pain |
| Event: | UCL (University College London) |
| Open access status: | An open access version is available from UCL Discovery |
| Language: | English |
| Additional information: | Copyright © The Author 2020. Original content in this thesis is licensed under the terms of the Creative Commons Attribution 4.0 International (CC BY 4.0) Licence (https://creativecommons.org/licenses/by/4.0/). Any third-party copyright material present remains the property of its respective owner(s) and is licensed under its existing terms. Access may initially be restricted at the author’s request. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10111770 |
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