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Materials roles for promoting angiogenesis in tissue regeneration

Lee, J-H; Parthiban, P; Jin, G-Z; Knowles, JC; Kim, H-W; (2020) Materials roles for promoting angiogenesis in tissue regeneration. Progress in Materials Science , Article 100732. 10.1016/j.pmatsci.2020.100732. (In press). Green open access

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Abstract

Enabling angiogenesis is critical for the success of tissue repair therapies and the fate of tissueengineered constructs. Although many biochemical signaling molecules have been used, their biological functions in vivo are known to be limited, mainly due to their short lifetime and poor activity. Matrices (or engineered biomaterials), beyond the biochemical signals, play pivotal roles in stimulating angiogenic processes. Here we discuss the proangiogenic effort taken to repair and regenerate various tissues including skin, bone, muscle and nerve, focusing on the roles of engineered matrices. This includes the design of pore structure and physico-chemical properties (nanotopology, stiffness, chemistry and degradability), the tailoring of matrices for proper presentation of growth factors and their crosstalks with adhesion ligands, the controlled and sustained delivery of angiogenic molecules and metallic ions, and the engineering of cells and construction of prevascularized tissues. Collectively, the materials-driven strategies are envisaged.

Type: Article
Title: Materials roles for promoting angiogenesis in tissue regeneration
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.pmatsci.2020.100732
Publisher version: http://dx.doi.org/10.1016/j.pmatsci.2020.100732
Language: English
Additional information: © 2020 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/).
Keywords: Angiogenesis, Tissue regeneration, Materials properties, Delivery, Cell engineering
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute > Biomaterials and Tissue Eng
URI: https://discovery.ucl.ac.uk/id/eprint/10110399
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