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Dynamic contextual modulation in superior colliculus of awake mouse

De Franceschi, G; Solomon, SG; (2020) Dynamic contextual modulation in superior colliculus of awake mouse. eNeuro 10.1523/eneuro.0131-20.2020. (In press). Green open access

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Abstract

The responses of neurons in the visual pathway depend on the context in which a stimulus is presented. Responses to predictable stimuli are usually suppressed, highlighting responses to unexpected stimuli that might be important for behaviour. Here we established how context modulates the response of neurons in the superior colliculus, a region important in orienting towards or away from visual stimuli. We made extracellular recordings from single-units in the superficial layers of superior colliculus in awake mice. We found strong suppression of visual response by spatial context (surround suppression) and temporal context (adaptation). Neurons showing stronger surround suppression also showed stronger adaptation effects. In neurons where it was present surround suppression was dynamic, and was reduced by adaptation. Adaptation’s effects further revealed two components to surround suppression: one component that was weakly tuned for orientation and adaptable, and another component that was more strongly tuned but less adaptable. The selectivity of the tuned component was flexible, such that suppression was stronger when the stimulus over the surround matched that over the receptive field. Our results therefore reveal strong interactions between spatial and temporal context in regulating the flow of signals through mouse superior colliculus, and suggest the presence of a subpopulation of neurons that might signal novelty in either space or time.

Type: Article
Title: Dynamic contextual modulation in superior colliculus of awake mouse
Open access status: An open access version is available from UCL Discovery
DOI: 10.1523/eneuro.0131-20.2020
Publisher version: https://doi.org/10.1523/eneuro.0131-20.2020
Language: English
Additional information: This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. http://creativecommons.org/licenses/by/4.0/
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Experimental Psychology
URI: https://discovery.ucl.ac.uk/id/eprint/10109274
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