Ward, H;
West, SJ;
(2020)
Microglia: sculptors of neuropathic pain?
Royal Society Open Science
, 7
(6)
, Article 200260. 10.1098/rsos.200260.
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Abstract
Neuropathic pain presents a huge societal and individual burden. The limited efficacy of current analgesics, diagnostic markers and clinical trial outcome measures arises from an incomplete understanding of the underlying mechanisms. A large and growing body of evidence has established the important role of microglia in the onset and possible maintenance of neuropathic pain, and these cells may represent an important target for future therapy. Microglial research has further revealed their important role in structural remodelling of the nervous system. In this review, we aim to explore the evidence for microglia in sculpting nervous system structure and function, as well as their important role in neuropathic pain, and finally integrate these studies to synthesize a new model for microglia in somatosensory circuit remodelling, composed of six key and inter-related mechanisms. Summarizing the mechanisms through which microglia modulate nervous system structure and function helps to frame a better understanding of neuropathic pain, and provide a clear roadmap for future research.
| Type: | Article |
|---|---|
| Title: | Microglia: sculptors of neuropathic pain? |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1098/rsos.200260 |
| Publisher version: | http://dx.doi.org/10.1098/rsos.200260 |
| Language: | English |
| Additional information: | © 2020 The Authors. Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited. |
| Keywords: | microglia, pain, neuropathy, SPINAL-CORD-INJURY, ROSTRAL VENTROMEDIAL MEDULLA, SUPERFICIAL DORSAL-HORN, NECROSIS-FACTOR-ALPHA, NERVE INJURY, SYNAPTIC PLASTICITY, GLIAL ACTIVATION, LAMINA-II, SUBSTANTIA-GELATINOSA, CENTRAL SENSITIZATION |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > The Sainsbury Wellcome Centre |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10107841 |
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