Van Assche, L;
Emsell, L;
Claes, L;
Van de Ven, L;
Luyten, P;
Van den Stock, J;
De Winter, F-L;
... Vandenbulcke, M; + view all
(2020)
Hippocampal volume as a vulnerability marker for late onset psychosis: associations with memory function and childhood trauma.
Schizophrenia Research
, 224
pp. 201-202.
10.1016/j.schres.2020.08.004.
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Abstract
In a considerable amount of individuals the onset of psychosis is delayed until later in life, even after the age of 60 years. This condition is referred to as very-late-onset schizophrenia-like psychosis (VLOSLP) and it is characterized by paranoid or partition delusions, as well as multimodal hallucinations (Howard et al., 2000). Although a delayed manifestation of psychotic symptoms appears counterintuitive, the life-cycle model of stress provides a well-established theoretical framework to understand associations between early adversity and late-onset psychopathology, suggesting that severe childhood distress causes the hyperactivation and sensitization of the hypothalamus-pituitary-adrenal (HPA) axis stimulating the production of glucocorticoids that exert lasting harmful effects on brain structures regulating stress such as the hippocampus, and hence leading to a lifelong increased vulnerability to the development of psychopathology (Lupien et al., 2009).
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