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Flow, suspension and mixing dynamics in DASGIP bioreactors, Part 2

Samaras, JJ; Ducci, A; Micheletti, M; (2020) Flow, suspension and mixing dynamics in DASGIP bioreactors, Part 2. AIChE Journal , 66 (11) , Article e16999. 10.1002/aic.16999. Green open access

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Abstract

This work aims to characterize the mixing and suspension dynamics occurring within two commercially available DASGIP bioreactor configurations, equipped with a two‐blade paddle impeller with large impeller to tank diameter ratio, D/T = 0.97. Both continuous and intermittent agitation modes were employed to determine the impact that agitation strategy has upon mass transfer and microcarrier settling/suspension. This paper builds upon the flow dynamics data presented in Part 1 for a flat bottom DASGIP bioreactor and shows how intermittent agitation can break‐up regions of slow mixing observed during continuous agitation, therefore substantially increasing the mixing efficiency of the system. Similarly, it was found that microcarrier characteristics might significantly affect the level of suspension when the impeller is in dwell status when intermittent agitation modes are used.

Type: Article
Title: Flow, suspension and mixing dynamics in DASGIP bioreactors, Part 2
Open access status: An open access version is available from UCL Discovery
DOI: 10.1002/aic.16999
Publisher version: https://doi.org/10.1002/aic.16999
Language: English
Additional information: © 2020 The Authors. AIChE Journal published by Wiley Periodicals LLC on behalf of American Institute of Chemical Engineers. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Keywords: agitation modes, DASGIP, microcarriers, mixing dynamics, suspension dynamics
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Biochemical Engineering
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Mechanical Engineering
URI: https://discovery.ucl.ac.uk/id/eprint/10107468
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