UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Pediatric Sepsis Definition-A Systematic Review Protocol by the Pediatric Sepsis Definition Taskforce

Menon, K; Schlapbach, LJ; Akech, S; Argent, A; Chiotos, K; Chisti, MJ; Hamid, J; ... Sorce, LR; + view all (2020) Pediatric Sepsis Definition-A Systematic Review Protocol by the Pediatric Sepsis Definition Taskforce. Critical Care Explorations , 2 (6) , Article e0123. 10.1097/CCE.0000000000000123. Green open access

[thumbnail of Pediatric_Sepsis_Definition_A_Systematic_Review.11.pdf]
Preview
Text
Pediatric_Sepsis_Definition_A_Systematic_Review.11.pdf - Published Version

Download (970kB) | Preview

Abstract

Objectives: Sepsis is responsible for a substantial proportion of global childhood morbidity and mortality. However, evidence demonstrates major inaccuracies in the use of the term “sepsis” in clinical practice, coding, and research. Current and previous definitions of sepsis have been developed using expert consensus but the specific criteria used to identify children with sepsis have not been rigorously evaluated. Therefore, as part of the Society of Critical Care Medicine’s Pediatric Sepsis Definition Taskforce, we will conduct a systematic review to synthesize evidence on individual factors, clinical criteria, or illness severity scores that may be used to identify children with infection who have or are at high risk of developing sepsis-associated organ dysfunction and separately those factors, criteria, and scores that may be used to identify children with sepsis who are at high risk of progressing to multiple organ dysfunction or death. Data Sources: We will identify eligible studies by searching the following databases: MEDLINE, Embase, and the Cochrane Central Register of Controlled Trials. Study Selection: We will include all randomized trials and cohort studies published between January 1, 2004, and March 16, 2020. Data Extraction: Data extraction will include information related to study characteristics, population characteristics, clinical criteria, and outcomes. Data Synthesis: We will calculate sensitivity and specificity of each criterion for predicting sepsis and conduct a meta-analysis if the data allow. We will also provide pooled estimates of overall hospital mortality. Conclusions: The potential risk factors, clinical criteria, and illness severity scores from this review which identify patients with infection who are at high risk of developing sepsis-associated organ dysfunction and/or progressing to multiple organ dysfunction or death will be used to inform the next steps of the Pediatric Sepsis Definition Taskforce.

Type: Article
Title: Pediatric Sepsis Definition-A Systematic Review Protocol by the Pediatric Sepsis Definition Taskforce
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1097/CCE.0000000000000123
Publisher version: https://doi.org/10.1097/CCE.0000000000000123
Language: English
Additional information: This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. http://creativecommons.org/licenses/by-nc-nd/4.0/
Keywords: childhood, infection, mortality, organ dysfunction, sepsis, septic shock
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Infection, Immunity and Inflammation Dept
URI: https://discovery.ucl.ac.uk/id/eprint/10106629
Downloads since deposit
58Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item