UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Low temperature coatings with aqueous formulations for oral colonic delivery of thermolabile materials

Leong, Chuei Wuei; (1996) Low temperature coatings with aqueous formulations for oral colonic delivery of thermolabile materials. Doctoral thesis (Ph.D.), University College London (United Kingdom). Green open access

[thumbnail of Low_temperature_coatings_with_.pdf]

Download (18MB) | Preview


Targeted oral delivery to the colon has previously been achieved with aqueous coatings of amylose and ethylcellulose applied at temperatures above 60°C. Such a high processing temperature may damage certain thermolabile drugs. Therefore, this study sets out to develop aqueous amylose-containing coating formulations which are suitable for use at temperatures below 37°C. The coating materials used were aqueous coating dispersions of an experimental grade of amylose blended with each of two commercial brands of ethylcellulose. In general, aqueous coating dispersions applied at low temperatures have the increased risk of incomplete film formation due to insufficient energy to ensure fusion of the polymer. Also, aqueous amylose-butanol complex coating dispersion has the increased risk of retaining butanol within the film. The quality of the film formed from the aqueous coating dispersions were assessed as cast isolated free films and as films sprayed onto pellets. Studies using free films showed that successful fusion of the films could be achieved using high quantities of effective plasticizers. The possible presence of residual butanol within the film was found to be minimal. The specific colon release performance of coating materials were assessed as spray-coats onto pellets containing 5-ASA and glucose pellets and tested in vitro. The ratio of ethylcellulose to amylose, the thickness of the films and the contents of plasticizer were all important influencing factors to ensuring the resistance of the spray-coats to premature drug release. Formulations containing (33.33 - 40)% of amylose, with (28 - 36)% of dibutyl sebacate as plasticizer, applied to 10% total weight gain, showed minimal 5-ASA release in the simulated upper gastrointestinal tract condition with significantly larger drug release in simulated colonic test conditions. However, these same coating formulations were not successful in preventing premature glucose release from the pellets. The success of these low temperature coating formulations appeared to be influenced by the solubility of the drug.

Type: Thesis (Doctoral)
Qualification: Ph.D.
Title: Low temperature coatings with aqueous formulations for oral colonic delivery of thermolabile materials
Open access status: An open access version is available from UCL Discovery
Language: English
Additional information: Thesis digitised by ProQuest.
Keywords: (UMI)AAI10104689; Health and environmental sciences; Coatings; Colonic; Delivery; Formulations; Oral; Temperature; Thermolabile
URI: https://discovery.ucl.ac.uk/id/eprint/10101820
Downloads since deposit
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item