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Mitochondrial ion channels as targets for cardioprotection

Hausenloy, DJ; Schulz, R; Girao, H; Kwak, BR; De Stefani, D; Rizzuto, R; Bernardi, P; (2020) Mitochondrial ion channels as targets for cardioprotection. Journal Of Cellular And Molecular Medicine 10.1111/jcmm.15341. (In press). Green open access

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Abstract

Acute myocardial infarction (AMI) and the heart failure (HF) that often result remain the leading causes of death and disability worldwide. As such, new therapeutic targets need to be discovered to protect the myocardium against acute ischaemia/reperfusion (I/R) injury in order to reduce myocardial infarct (MI) size, preserve left ventricular function and prevent the onset of HF. Mitochondrial dysfunction during acute I/R injury is a critical determinant of cell death following AMI, and therefore, ion channels in the inner mitochondrial membrane, which are known to influence cell death and survival, provide potential therapeutic targets for cardioprotection. In this article, we review the role of mitochondrial ion channels, which are known to modulate susceptibility to acute myocardial I/R injury, and we explore their potential roles as therapeutic targets for reducing MI size and preventing HF following AMI.

Type: Article
Title: Mitochondrial ion channels as targets for cardioprotection
Open access status: An open access version is available from UCL Discovery
DOI: 10.1111/jcmm.15341
Publisher version: https://doi.org/10.1111/jcmm.15341
Language: English
Additional information: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0/
Keywords: acute ischaemia/reperfusion injury, cardioprotection, Mitochondria, mitochondrial permeability transition pore
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science > Pre-clinical and Fundamental Science
URI: https://discovery.ucl.ac.uk/id/eprint/10101143
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