Di Lorenzo, F;
Motta, C;
Casula, EP;
Bonnì, S;
Assogna, M;
Caltagirone, C;
Martorana, A;
(2020)
LTP-like cortical plasticity predicts conversion to dementia in patients with memory impairment.
Brain Stimulation
, 13
(5)
pp. 1175-1182.
10.1016/j.brs.2020.05.013.
(In press).
Preview |
Text
1-s2.0-S1935861X20301121-main.pdf - Published Version Download (840kB) | Preview |
Abstract
Background: New diagnostic criteria consider Alzheimer’s disease (AD) as a clinico-biological entity identifiable in vivo on the presence of specific patterns of CSF biomarkers. Objective: Here we used transcranial magnetic stimulation to investigate the mechanisms of cortical plasticity and sensory-motor integration in patients with hippocampal-type memory impairment admitted for the first time in the memory clinic stratified according to CSF biomarkers profile. Methods: Seventy-three patients were recruited and divided in three groups according to the new diagnostic criteria: 1) Mild Cognitive Impaired (MCI) patients (n ¼ 21); Prodromal AD (PROAD) patients (n ¼ 24); AD with manifest dementia (ADD) patients (n ¼ 28). At time of recruitment all patients underwent CSF sampling for diagnostic purposes. Repetitive and paired-pulse transcranial magnetic stimulation protocols were performed to investigate LTP-like and LTD-like cortical plasticity, short intracortical inhibition (SICI) and short afferent inhibition (SAI). Patients were the followed up during three years to monitor the clinical progression or the conversion to dementia. Results: MCI patients showed a moderate but significant impairment of LTP-like cortical plasticity, while ADD and PROAD groups showed a more severe loss of LTP-like cortical plasticity. No differences were observed for LTD-like cortical plasticity, SICI and SAI protocols. Kaplan-Meyer analyses showed that PROAD and MCI patients converting to dementia had weaker LTP-like plasticity at time of first evaluation. Conclusion: LTP-like cortical plasticity could be a novel biomarker to predict the clinical progression to dementia in patients with memory impairmen
| Type: | Article |
|---|---|
| Title: | LTP-like cortical plasticity predicts conversion to dementia in patients with memory impairment |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.brs.2020.05.013 |
| Publisher version: | https://doi.org/10.1016/j.brs.2020.05.013 |
| Language: | English |
| Additional information: | This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/) |
| Keywords: | Alzheimer’s disease Transcranial magnetic stimulation, Mild cognitive impairment, Memory, Long term potentiation, Biomarker, TMS |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10100213 |
Archive Staff Only
 |
View Item |
