UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Reimagining Flow Cytometric Cell Sorting

Jayasinghe, SN; (2020) Reimagining Flow Cytometric Cell Sorting. Advanced Biosystems , Article e2000019. 10.1002/adbi.202000019. (In press). Green open access

[thumbnail of adbi.202000019.pdf]
adbi.202000019.pdf - Published Version

Download (1MB) | Preview


In this review, a brief history of this unrivaled technology, flow cytometry, is provided, highlighting its past and present advances, with particular focus on "flow cell" technologies. Flow cytometry has truly revolutionized high-throughput single cell analysis, which has tremendous implications, from laboratory to the clinic. This technology embodies what is truly referred to as cross fertile research, merging the physical with the life sciences. This review introduces the recent notable advancements in flow cell technology. This advancement sees the complete removal of liquid sheath flow, which has advanced the technology with the possibility of both the reduction in its foot print, while also simplifying the flow cells explored in cytometry. Interestingly, the novel sheathless flow cell technology demonstrated herein has the flexibility for handling both heterogeneous cell populations and whole organisms, thus demonstrating a versatile flow cell technology for both flow cytometry and fluorescent-activated cell sorting.

Type: Article
Title: Reimagining Flow Cytometric Cell Sorting
Location: Germany
Open access status: An open access version is available from UCL Discovery
DOI: 10.1002/adbi.202000019
Publisher version: http://dx.doi.org/10.1002/adbi.202000019
Language: English
Additional information: © 2020 The Authors. Published by WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Keywords: FACS, aerodynamically assisted biojets, cell sorting, flow cells, sheathless flow cytometry, single cell diagnostics
UCL classification: UCL
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Mechanical Engineering
URI: https://discovery.ucl.ac.uk/id/eprint/10100203
Downloads since deposit
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item