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Hemostatic spray powder TC-325 in the primary endoscopic treatment of peptic ulcer related bleeding: multicentre international registry

Hussein, M; Alzoubaidi, D; Fraile-López, M; Weaver, M; Ortiz-Fernández-Sordo', J; Bassett, P; Rey, J; ... Haidry, R; + view all (2021) Hemostatic spray powder TC-325 in the primary endoscopic treatment of peptic ulcer related bleeding: multicentre international registry. Endoscopy , 53 (1) pp. 36-43. 10.1055/a-1186-5360. Green open access

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Abstract

Introduction: Upper gastrointestinal bleeding (UGIB) is a leading cause of morbidity and associated with a 2-17% mortality in the United Kingdom (UK) and USA [1]. Peptic ulcers account for 50% of UGIB’s. Endoscopic intervention in a timely manner can improve outcomes. Hemospray (Cook Medical, North Carolina, USA) is an endoscopic haemostatic powder for GI bleeding. This multicentre registry was created to collect data prospectively on the immediate Endoscopic haemostasis of GI bleeding in patients with peptic ulcer disease when Hemospray is applied as endoscopic monotherapy, dual therapy or rescue therapy. / Methods: Data were collected prospectively (January 2016 – March 2019) from 14 centres in the (UK, France, Germany and the USA). The application of Hemospray was decided upon at the endoscopist’s discretion. / Results: 202 patients with UGIB secondary to peptic ulcers were recruited. Immediate haemostasis was achieved in 178/202 (88%) of patients, 26/154 (17%) had a re-bleed, 21/175 (12%) died within 7 days, 38/175 (22%) died within 30 days (all-cause mortality). Hemospray combination therapy with other endoscopic modalities had an associated lower 30-day mortality (16%, P <0.05) relative to Hemospray monotherapy or rescue therapy. There were high immediate haemostasis rates across all PUD Forrest classifications. / Conclusions: This is the largest case series of outcomes of peptic ulcer bleeds treated with Hemospray. There were high immediate haemostasis rates with Hemospray in oesophageal and peptic ulcer bleeds.

Type: Article
Title: Hemostatic spray powder TC-325 in the primary endoscopic treatment of peptic ulcer related bleeding: multicentre international registry
Location: Germany
Open access status: An open access version is available from UCL Discovery
DOI: 10.1055/a-1186-5360
Publisher version: https://doi.org/10.1055/a-1186-5360
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Endoscopy, Hemospray, Peptic ulcer, GI bleed
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Targeted Intervention
URI: https://discovery.ucl.ac.uk/id/eprint/10099004
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