Cuevas, E;
Parmar, P;
Sowden, JC;
(2019)
Restoring Vision Using Stem Cells and Transplantation.
In: Rickman, CB and Grimm, C and Anderson, RE and Ash, JD and LaVail, MM and Hollyfield, JG, (eds.)
Retinal Degenerative Diseases.
(pp. pp. 563-567).
Springer Nature
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Abstract
The replacement of retinal cells, or the support of surviving retinal neurons, in a degenerated retina presents a significant challenge in the fields of ophthalmology and regenerative medicine. Stem cell-based therapies are being explored as an approach for treating retinal dystrophies, such as retinitis pigmentosa (RP), Stargardt’s disease, and age-related macular degeneration (AMD). This review provides an update on the recent progress made toward the restoration of vision lost to degenerative disease using stem cell-based transplantation strategies and the challenges that need to be overcome. Both retinal pigmented epithelium (RPE) and photoreceptor replacement therapies are discussed.
| Type: | Proceedings paper |
|---|---|
| Title: | Restoring Vision Using Stem Cells and Transplantation |
| Event: | 18th International Symposium on Retinal Degeneration (RD) |
| Location: | Killarney, Ireland |
| Dates: | 3rd-8th September 2018 |
| ISBN-13: | 978-3-030-27377-4 |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1007/978-3-030-27378-1_92 |
| Publisher version: | https://doi.org/10.1007/978-3-030-27378-1 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions. |
| Keywords: | Cell therapy, Cell transplantation, Retinal degeneration, Retinitis pigmentosa, Age-related macular disease, Stem cell therapy, Retinal organoids, Translational research, In vitro retinal pigmented epithelium, In vitro photoreceptor cells |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Biology and Cancer Dept |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10098859 |
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