UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Evaluating the measurement properties of patient-reported outcome measures in radiotherapy-induced xerostomia

Assas, M; Wiriyakijja, P; Fedele, S; Porter, S; Ní Ríordáin, R; (2020) Evaluating the measurement properties of patient-reported outcome measures in radiotherapy-induced xerostomia. Oral Diseases 10.1111/odi.13416. (In press). Green open access

[img]
Preview
Text
odi.13416.pdf - Accepted version

Download (10MB) | Preview

Abstract

Objective: Radiotherapy‐induced xerostomia (RIX) is one of the most common adverse effects of radiotherapy to the head and neck, and a major determinant of survivors’ quality of life. A number of patient‐reported outcome measures (PROMs) have been used in clinical trials of therapeutic interventions for RIX; however, little is known regarding their measurement properties and methodological quality. Methods: We conducted a systematic literature search in Embase, MEDLINE and PsycINFO for articles published up to May 2019 and evaluating at least one measurement property of PROMs relevant to RIX. The COSMIN guidelines were used to assess relevant measurement properties and methodological quality. Results: Nine validations studies were identified reporting on four PROMs relevant to RIX. The Xerostomia Questionnaire (XQ) showed overall high‐quality evidence for structural validity and internal consistency, but low‐quality evidence supporting reliability. The methodological quality of the Groningen Radiotherapy‐Induced Xerostomia scale (GRIX), Xerostomia Inventory (XI) and the Xerostomia Quality of Life Scale (XeQoLS) was relatively low for all measurement properties. Conclusions: The XQ was found to have the highest potential to capture changes in RIX according to COSMIN guidelines. Additional validation studies are required to further understand the methodological quality of the XI, GRIX and XeQoLS.

Type: Article
Title: Evaluating the measurement properties of patient-reported outcome measures in radiotherapy-induced xerostomia
Location: Denmark
Open access status: An open access version is available from UCL Discovery
DOI: 10.1111/odi.13416
Publisher version: https://doi.org/10.1111/odi.13416
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute > EDI MaxFac, Diagnostic, Med and Surg Sci
URI: https://discovery.ucl.ac.uk/id/eprint/10098588
Downloads since deposit
11Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item