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Mesoporous Strontium-Doped Phosphate-Based Sol-Gel Glasses for Biomedical Applications

Foroutan, F; Kyffin, BA; Abrahams, I; Knowles, JC; Sogne, E; Falqui, A; Carta, D; (2020) Mesoporous Strontium-Doped Phosphate-Based Sol-Gel Glasses for Biomedical Applications. Frontiers in Chemistry , 8 , Article 249. 10.3389/fchem.2020.00249. Green open access

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Abstract

Mesoporous phosphate-based glasses have great potential as biomedical materials being able to simultaneously induce tissue regeneration and controlled release of therapeutic molecules. In the present study, a series of mesoporous phosphate-based glasses in the P2O5-CaO-Na2O system, doped with 1, 3, and 5 mol% of Sr2+, were prepared using the sol-gel method combined with supramolecular templating. A sample without strontium addition was prepared for comparison. The non-ionic triblock copolymer EO20PO70EO20 (P123) was used as a templating agent. Scanning electron microscopy (SEM) images revealed that all synthesized glasses have an extended porous structure. This was confirmed by N2 adsorption-desorption analysis at 77 K that shows a porosity typical of mesoporous materials. 31P magic angle spinning nuclear magnetic resonance (31P MAS-NMR) and Fourier transform infrared (FTIR) spectroscopies have shown that the glasses are mainly formed by Q1 and Q2 phosphate groups. Degradation of the glasses in deionized water assessed over a 7-day period shows that phosphate, Ca2+, Na+, and Sr2+ ions can be released in a controlled manner over time. In particular, a direct correlation between strontium content and degradation rate was observed. This study shows that Sr-doped mesoporous phosphate-based glasses have great potential in bone tissue regeneration as materials for controlled delivery of therapeutic ions.

Type: Article
Title: Mesoporous Strontium-Doped Phosphate-Based Sol-Gel Glasses for Biomedical Applications
Location: Switzerland
Open access status: An open access version is available from UCL Discovery
DOI: 10.3389/fchem.2020.00249
Publisher version: https://doi.org/10.3389/fchem.2020.00249
Language: English
Additional information: Copyright © 2020 Foroutan, Kyffin, Abrahams, Knowles, Sogne, Falqui and Carta. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (http://creativecommons.org/licenses/by/4.0/). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Keywords: phosphate-based glasses, strontium-doped, tissue engineering, bioresorbable glasses, sol-gel
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute > Biomaterials and Tissue Eng
URI: https://discovery.ucl.ac.uk/id/eprint/10097553
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