Pucino, V;
Certo, M;
Bulusu, V;
Cucchi, D;
Goldmann, K;
Pontarini, E;
Haas, R;
... Mauro, C; + view all
(2019)
Lactate Buildup at the Site of Chronic Inflammation Promotes Disease by Inducing CD4⁺ T Cell Metabolic Rewiring.
Cell Metabolism
, 30
(6)
1055-1074.e8.
10.1016/j.cmet.2019.10.004.
Preview |
Text
Kurian_Structural analysis of pathogenic missense mutations in GABRA2 and identification of a novel de novo variant in the desensitization gate_AOP.pdf - Published Version Download (2MB) | Preview |
Abstract
Accumulation of lactate in the tissue microenvironment is a feature of both inflammatory disease and cancer. Here, we assess the response of immune cells to lactate in the context of chronic inflammation. We report that lactate accumulation in the inflamed tissue contributes to the upregulation of the lactate transporter SLC5A12 by human CD4+ T cells. SLC5A12-mediated lactate uptake into CD4+ T cells induces a reshaping of their effector phenotype, resulting in increased IL17 production via nuclear PKM2/STAT3 and enhanced fatty acid synthesis. It also leads to CD4+ T cell retention in the inflamed tissue as a consequence of reduced glycolysis and enhanced fatty acid synthesis. Furthermore, antibody-mediated blockade of SLC5A12 ameliorates the disease severity in a murine model of arthritis. Finally, we propose that lactate/SLC5A12-induced metabolic reprogramming is a distinctive feature of lymphoid synovitis in rheumatoid arthritis patients and a potential therapeutic target in chronic inflammatory disorders.
| Type: | Article |
|---|---|
| Title: | Lactate Buildup at the Site of Chronic Inflammation Promotes Disease by Inducing CD4⁺ T Cell Metabolic Rewiring |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.cmet.2019.10.004 |
| Publisher version: | https://doi.org/10.1016/j.cmet.2019.10.004 |
| Language: | English |
| Additional information: | Copyright © 2019 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| Keywords: | lactate, lactate transporter, signaling, inflammation, immunometabolism, T cell, translational research, cytokines, metabolic crosstalk |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10097322 |
Archive Staff Only
 |
View Item |
