Khawaja, AP; Campbell, JH; Kirby, N; Chandwani, HS; Keyzor, I; Parekh, M; McNaught, AI; ... Lydia, C; + view all Khawaja, AP; Campbell, JH; Kirby, N; Chandwani, HS; Keyzor, I; Parekh, M; McNaught, AI; Vincent, D; Angela, K; Nitin, A; Gbemi, O; Andrew, M; Lydia, C; - view fewer (2019) Real-World Outcomes of Selective Laser Trabeculoplasty in the United Kingdom. Ophthalmology 10.1016/j.ophtha.2019.11.017. (In press).

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Text Khawaja et al. - 2019 - Ophthalmology - Real-World Outcomes of Selective Laser Trabeculoplasty in the United Kingdom.pdf - Published Version Download (1MB) | Preview

Abstract

Purpose: Selective laser trabeculoplasty (SLT) is a common treatment option for managing glaucoma and ocular hypertension. We assessed the real-world effectiveness of SLT and baseline factors associated with treatment success in the United Kingdom. Design: Retrospective observational study of de-identified electronic medical records (Medisoft Glaucoma module [Medisoft Ltd, Leeds, UK]) from 5 UK ophthalmology teaching centers. Participants: Adult patients undergoing their first recorded SLT. For bilateral SLT (same day), analyses included 1 randomly selected eye. Methods: Patient demographics, procedure details, and clinical outcomes data were extracted. Factors associated with treatment success were assessed using multivariable Cox regression. Main Outcome Measures: Change from baseline in intraocular pressure (IOP) and glaucoma medication use at 12 to 18 and 24 to 36 months post-SLT. A Kaplan–Meier survival analysis was also conducted. Failure of SLT was defined as any further glaucoma procedure post-SLT or any of the following at 2 consecutive visits: IOP >21 mmHg, IOP reduction <20% from baseline, or increase in glaucoma medications from baseline. Results: A total of 831 SLT-treated eyes (mean baseline IOP 22.0 mmHg) of 831 patients were analyzed. At 12 to 18 and 24 to 36 months post-SLT, respectively, significant reductions in IOP (−4.2 [95% confidence interval {CI}, −4.7 to −3.7] and −3.4 [95% CI, −4.1 to −2.7] mmHg; both P < 0.0001) and significant increases in the number of glaucoma medications (0.13 [95% CI, 0.04–0.23], P = 0.007, and 0.20 [95% CI, 0.06–0.33], P = 0.005) were observed. Survival analysis demonstrated treatment success in 70%, 45%, and 27% of eyes at 6, 12, and 24 months post-SLT, respectively. Higher baseline IOP was strongly associated with treatment success (hazard ratio [HR], 0.67 for baseline IOP >21 mmHg vs. ≤21 mmHg, 95% CI, 0.57–0.80; P < 0.001). Selective laser trabeculoplasty success was not significantly associated with age (P = 0.78), baseline visual field mean deviation (P = 1.00), or concurrent use of IOP-lowering medication (P = 0.52). Conclusions: Most patients initially responded to SLT, but the majority failed within 1 year. Efficacy of SLT was better in patients with higher baseline IOP but did not differ by glaucoma severity or concurrent use of IOP-lowering medication. These findings may help inform which patients are suitable for SLT therapy.

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