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Effects of radiation exposure on dermal collagen: A multi modal approach

Maeva, A; Bamber, J; Seviaryna, I; Hopper, C; Perrett, C; Bozec, L; (2020) Effects of radiation exposure on dermal collagen: A multi modal approach. In: Proc. SPIE 11319, Medical Imaging 2020: Ultrasonic Imaging and Tomography. (pp. 113190P). SPIE: Houston, Texas, United States. Green open access

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Abstract

Intense pulsed light (IPL) is a high-intensity treatment for skin disorders and ageing. As this treatment regime is often poorly regulated and inadequately studied, we investigate IPL as a cosmetic device and its effects on dermal collagen components of the skin. Biopsies from the back-neck folds of a 4-week-old, 25 kg large white pig were irradiated with intense pulsed light (IPL) (l= 584 nm) at an increased radiation dose of 40 J/cm2 once, thrice and ten times. Samples were cryo-sectioned (10 μm) and stained with picro sirrus red. Ex-vivo biopsies were assessed with polarized light microscopy (PLM), atomic force microscopy (AFM) and scanning acoustic microscopy. Customized software was used to map the sound speed and attenuation on the ultrasonic images Differences in collagen structure were observed between all three levels of irradiation progressing depth-wise into the epidermis. Ex-vivo porcine tissue demonstrated loss of D-banding and gelatinization with increasing dermal depth with higher intensities. Acoustic microscopy demonstrated a significant decrease in sound speed and attenuation that relates to the number of exposures. Sound speed decreases at much faster rates than attenuation.

Type: Proceedings paper
Title: Effects of radiation exposure on dermal collagen: A multi modal approach
Event: SPIE Medical Imaging, 2020
Open access status: An open access version is available from UCL Discovery
DOI: 10.1117/12.2549843
Publisher version: https://doi.org/10.1117/12.2549843
Language: English
Additional information: This version is the version of record. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute > EDI MaxFac, Diagnostic, Med and Surg Sci
URI: https://discovery.ucl.ac.uk/id/eprint/10095027
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