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Assessment of antimicrobial use and prescribing practices among pediatric inpatients in Zimbabwe

Olaru, ID; Meierkord, A; Godman, B; Ngwenya, C; Fitzgerald, F; Dondo, V; Ferrand, RA; (2020) Assessment of antimicrobial use and prescribing practices among pediatric inpatients in Zimbabwe. Journal of Chemotherapy , 32 (8) pp. 456-459. 10.1080/1120009X.2020.1734719. Green open access

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Abstract

This study aims to assess antimicrobial consumption in the pediatric department of a tertiary care public hospital in Zimbabwe. Clinical records of pediatric inpatients admitted to Harare Central Hospital over a 3-week period were reviewed prospectively. Antimicrobial consumption was described as days of therapy per 100 inpatient days (DOT/100 PD). Adherence of antimicrobial drug prescriptions to the National Guidelines was also evaluated. A total of 121 (93.1%) children were prescribed at least one antimicrobial out of 130 children admitted. The median age was 14 months (IQR: 3 - 48 months). Overall antimicrobial consumption was 155.4 DOT/100 PD (95% CI 146-165.2). The most frequently prescribed antimicrobials were benzylpenicillin, gentamicin and ceftriaxone. Prescriptions were adherent to national guidelines in 57.7% of children. This study shows that there is high antimicrobial drug usage in hospitalized children in Zimbabwe and a considerable proportion of prescriptions are non-adherent with national guidelines.

Type: Article
Title: Assessment of antimicrobial use and prescribing practices among pediatric inpatients in Zimbabwe
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1080/1120009X.2020.1734719
Publisher version: https://doi.org/10.1080/1120009X.2020.1734719
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: AMR, Antibiotic resistance, Antimicrobial consumption, Antimicrobial resistance, Antimicrobial stewardship, Children
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Infection, Immunity and Inflammation Dept
URI: https://discovery.ucl.ac.uk/id/eprint/10094845
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