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Antiphospholipid Antibody Testing in a General Population Sample from the USA: An Administrative Database Study

Egiziano, G; Widdifield, J; Rahman, A; Vinet, E; Moura, CS; Curtis, JR; Bernatsky, S; (2020) Antiphospholipid Antibody Testing in a General Population Sample from the USA: An Administrative Database Study. Scientific Reports , 10 (1) , Article 3102. 10.1038/s41598-020-59990-5. Green open access

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Abstract

We sought to characterized patterns of aPL testing in a large general population sample from the United States. Using Truven Health MarketScan laboratory data from 2010-2015 we identified individuals tested for lupus anticoagulant(LA), anti-cardiolipin (aCL), and anti-beta2-glycoprotein1(aGP1). Our research was approved by the McGill institutional review board (A04-M47-12B). We identified 33,456 individuals with at least one aPL test. Among these, only 6,391 (19%) had all three tests (LA, aCL, aGP1) performed. Confirmatory aPL testing was performed at least 12 weeks later in 77%, 45%, and 41% of initially positive LA, aCL, and aGP1, respectively. Of those re-tested after ≥12 weeks, only 255 (10.6%) were found to have a confirmatory positive aPL test. These findings highlight that aPL testing may often be incompletely performed. Further investigations will be required to better understand the low rate of a confirmatory positive aPL test ≥12 weeks after the initial test.

Type: Article
Title: Antiphospholipid Antibody Testing in a General Population Sample from the USA: An Administrative Database Study
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1038/s41598-020-59990-5
Publisher version: https://doi.org/10.1038/s41598-020-59990-5
Language: English
Additional information: © The Author(s) 2020. This article is licensed under a Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/).
Keywords: Risk factors, Systemic lupus erythematosus
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inflammation
URI: https://discovery.ucl.ac.uk/id/eprint/10093449
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