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Photochemical Internalization for Intracellular Drug Delivery. From Basic Mechanisms to Clinical Research

Jerjes, W; Theodossiou, TA; Hirschberg, H; Høgset, A; Weyergang, A; Selbo, PK; Hamdoon, Z; ... Berg, K; + view all (2020) Photochemical Internalization for Intracellular Drug Delivery. From Basic Mechanisms to Clinical Research. Journal Of Clinical Medicine , 9 (2) , Article 528. 10.3390/jcm9020528. Green open access

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Abstract

Photochemical internalisation (PCI) is a unique intervention which involves the release of endocytosed macromolecules into the cytoplasmic matrix. PCI is based on the use of photosensitizers placed in endocytic vesicles that, following light activation, lead to rupture of the endocytic vesicles and the release of the macromolecules into the cytoplasmic matrix. This technology has been shown to improve the biological activity of a number of macromolecules that do not readily penetrate the plasma membrane, including type I ribosome-inactivating proteins (RIPs), gene-encoding plasmids, adenovirus and oligonucleotides and certain chemotherapeutics, such as bleomycin. This new intervention has also been found appealing for intracellular delivery of drugs incorporated into nanocarriers and for cancer vaccination. PCI is currently being evaluated in clinical trials. Data from the first-in-human phase I clinical trial as well as an update on the development of the PCI technology towards clinical practice is presented here.

Type: Article
Title: Photochemical Internalization for Intracellular Drug Delivery. From Basic Mechanisms to Clinical Research
Location: Switzerland
Open access status: An open access version is available from UCL Discovery
DOI: 10.3390/jcm9020528
Publisher version: https://doi.org/10.3390/jcm9020528
Language: English
Additional information: © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
Keywords: photochemical internalization; photodynamic; drug delivery; endocytosis; lysosomes; nanotechnology; immunotoxin; nucleic acids; gene therapy; bleomycin
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute > EDI MaxFac, Diagnostic, Med and Surg Sci
URI: https://discovery.ucl.ac.uk/id/eprint/10093292
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