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Acute and chronic effects of Δ⁹-tetrahydrocannabinol (THC) on cerebral blood flow: A systematic review

Ogunbiyi, MO; Hindocha, C; Freeman, TP; Bloomfield, MAP; (2020) Acute and chronic effects of Δ⁹-tetrahydrocannabinol (THC) on cerebral blood flow: A systematic review. Progress in Neuro-Psychopharmacology and Biological Psychiatry , Article 109900. 10.1016/j.pnpbp.2020.109900. (In press).

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Abstract

Acute and chronic exposure to cannabis and its main psychoactive component, 9-tetrahydrocannabinol (THC), is associated with changes in brain function and cerebral blood flow (CBF). We therefore sought to systematically review the literature on the effects of THC on CBF following PRISMA guidelines. Studies assessing the acute and chronic effects of THC on CBF, perfusion and volume were searched in the PubMed database between January 1972 and June 2019. We included thirty-four studies, which altogether investigated 1259 humans and 28 animals. Acute and chronic THC exposure have contrasting and regionally specific effects on CBF. While acute THC causes an overall increase in CBF in the anterior cingulate cortex, frontal cortex and insula, in a dose-dependent manner, chronic cannabis use results in an overall reduction in CBF, especially in the prefrontal cortex, which may be reversed upon prolonged abstinence from the drug. Future studies should focus on standardised methodology and longitudinal assessment to strengthen our understanding of the region-specific effects of THC on CBF and its clinical and functional significance.

Type: Article
Title: Acute and chronic effects of Δ⁹-tetrahydrocannabinol (THC) on cerebral blood flow: A systematic review
Location: England
DOI: 10.1016/j.pnpbp.2020.109900
Publisher version: https://doi.org/10.1016/j.pnpbp.2020.109900
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: CBF, Cannabinoid, Cannabis, Cerebral blood flow, THC, Tetrahydrocannabinol
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Clinical, Edu and Hlth Psychology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Division of Psychiatry
URI: https://discovery.ucl.ac.uk/id/eprint/10093177
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