Paraschiv, A;
Hegde, S;
Ganti, R;
Pilizota, T;
Šarić, A;
(2020)
Dynamic Clustering Regulates Activity of Mechanosensitive Membrane Channels.
Physical Review Letters
, 124
(4)
, Article 048102. 10.1103/PhysRevLett.124.048102.
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Abstract
Experiments have suggested that bacterial mechanosensitive channels separate into 2D clusters, the role of which is unclear. By developing a coarse-grained computer model we find that clustering promotes the channel closure, which is highly dependent on the channel concentration and membrane stress. This behaviour yields a tightly regulated gating system, whereby at high tensions channels gate individually, and at lower tensions the channels spontaneously aggregate and inactivate. We implement this positive feedback into the model for cell volume regulation, and find that the channel clustering protects the cell against excessive loss of cytoplasmic content.
| Type: | Article |
|---|---|
| Title: | Dynamic Clustering Regulates Activity of Mechanosensitive Membrane Channels |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1103/PhysRevLett.124.048102 |
| Publisher version: | https://doi.org/10.1103/PhysRevLett.124.048102 |
| Language: | English |
| Additional information: | This version is the version of record. For information on re-use, please refer to the publisher’s terms and conditions. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Physics and Astronomy |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10092834 |
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