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Testing Shortened Versions of Smell Tests to Screen for Hyposmia in Parkinson's Disease

Auger, SD; Kanavou, S; Lawton, M; Ben‐Shlomo, Y; Hu, MT; Schrag, AE; Morris, HR; ... Noyce, AJ; + view all (2020) Testing Shortened Versions of Smell Tests to Screen for Hyposmia in Parkinson's Disease. Movement Disorders Clinical Practice , 7 (4) pp. 394-398. 10.1002/mdc3.12928. Green open access

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Abstract

Background: Hyposmia is an early feature in neurodegenerative diseases, most notably Parkinson's Disease (PD). Using abbreviated smell tests could provide a cost‐effective means for large‐scale hyposmia screening. It is unclear whether short smell tests can effectively detect hyposmia in patient populations. / Objectives: To test the ability of short smell combinations to ‘pre‐screen' for probable hyposmia in people with PD and target administration of more extensive tests, such as the University of Pennsylvania Smell Identification Test (UPSIT). / Methods: We assessed the screening performance of a short 4 smell combination previously derived from use of the 40‐item UPSIT in healthy older people and its ability to detect hyposmia in a large cohort of PD patients. / Results: The novel 4 smell combination included Menthol, Clove, Onion and Orange and had a sensitivity of 87.1% (95% confidence interval: 84.9%‐89.2%) and specificity of 69.7% (63.3%‐75.5%) for detecting hyposmia in patients with PD. A different (also novel) 4‐item combination developed using a data‐driven approach in PD patients only achieved 81.3% (78.2%‐84.4%) sensitivity for equivalent specificity. / Conclusions: A short 4 smell combination derived from a healthy population demonstrated high sensitivity to detect those with hyposmia and PD.

Type: Article
Title: Testing Shortened Versions of Smell Tests to Screen for Hyposmia in Parkinson's Disease
Open access status: An open access version is available from UCL Discovery
DOI: 10.1002/mdc3.12928
Publisher version: http://dx.doi.org/10.1002/mdc3.12928
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences
URI: https://discovery.ucl.ac.uk/id/eprint/10092704
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