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Measuring diffusion exchange across the cell membrane with DEXSY (Diffusion Exchange Spectroscopy)

Breen-Norris, JO; Siow, B; Walsh, C; Hipwell, B; Hill, I; Roberts, T; Hall, MG; ... Walker-Samuel, S; + view all (2020) Measuring diffusion exchange across the cell membrane with DEXSY (Diffusion Exchange Spectroscopy). Magnetic Resonance in Medicine 10.1002/mrm.28207. (In press). Green open access

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Abstract

INTRODUCTION: To combine numerical simulations, in vitro and in vivo experiments to evaluate the feasibility of measuring diffusion exchange across the cell membrane with diffusion exchange spectroscopy (DEXSY). METHODS: DEXSY acquisitions were simulated over a range of permeabilities in nerve tissue and yeast substrates. In vitro measurements were performed in a yeast substrate and in vivo measurements in mouse tumor xenograft models, all at 9.4 T. RESULTS: Diffusion exchange was observed in simulations over a physiologically relevant range of cell permeability values. In vitro and in vivo measures also provided evidence of diffusion exchange, which was quantified with the Diffusion Exchange Index (DEI). CONCLUSIONS: Our findings provide preliminary evidence that DEXSY can be used to make in vivo measurements of diffusion exchange and cell membrane permeability.

Type: Article
Title: Measuring diffusion exchange across the cell membrane with DEXSY (Diffusion Exchange Spectroscopy)
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1002/mrm.28207
Publisher version: http://dx.doi.org/10.1002/mrm.28207
Language: English
Additional information: © 2020 The Authors. Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine.
Keywords: DEXSY, Diffusion exchange, FEXSY, cell membrane permeability
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Department of Imaging
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Experimental and Translational Medicine
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Computer Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Mechanical Engineering
URI: https://discovery.ucl.ac.uk/id/eprint/10092637
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