Breen-Norris, JO;
Siow, B;
Walsh, C;
Hipwell, B;
Hill, I;
Roberts, T;
Hall, MG;
... Walker-Samuel, S; + view all
(2020)
Measuring diffusion exchange across the cell membrane with DEXSY (Diffusion Exchange Spectroscopy).
Magnetic Resonance in Medicine
10.1002/mrm.28207.
(In press).
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Abstract
INTRODUCTION: To combine numerical simulations, in vitro and in vivo experiments to evaluate the feasibility of measuring diffusion exchange across the cell membrane with diffusion exchange spectroscopy (DEXSY). METHODS: DEXSY acquisitions were simulated over a range of permeabilities in nerve tissue and yeast substrates. In vitro measurements were performed in a yeast substrate and in vivo measurements in mouse tumor xenograft models, all at 9.4 T. RESULTS: Diffusion exchange was observed in simulations over a physiologically relevant range of cell permeability values. In vitro and in vivo measures also provided evidence of diffusion exchange, which was quantified with the Diffusion Exchange Index (DEI). CONCLUSIONS: Our findings provide preliminary evidence that DEXSY can be used to make in vivo measurements of diffusion exchange and cell membrane permeability.
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