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Implantable composite fibres with Self-supplied H2O2 for localized chemodynamic therapy

Wang, G; Gao, J; Fu, Y; Ren, Z; Huang, J; Li, X; Han, G; (2020) Implantable composite fibres with Self-supplied H2O2 for localized chemodynamic therapy. Chemical Engineering Journal , 388 , Article 124211. 10.1016/j.cej.2020.124211. Green open access

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Abstract

The anticancer efficacy of chemodynamic therapy (CDT) is considerably restrained by the inadequate content of H2O2 within tumor microenvironment (TME), unexpected oxidation of Fenton agents and low targeting efficiency of particulate therapeutic platforms. Herein for the first time, an implantable CDT platform was designed and synthesized by combining Fe0 nanocrystal embedded mesoporous silica nanoparticles (FeMSN) and PCL-gelatin fibres (PG fibres), denoted as FeMSN@PG fibres. FeMSN was fabricated via in situ reduction of ferrous ions within the mesopores of MSNs, and assembled at the surface of electrospun PG fibres by electrostatic interaction to form a fibrous mesh. The findings reflected that, in an acid condition, FeMSN nanoparticles can liberate from the composite fibres, and be effectively uptaken by 4T1 cancer cells. The FeMSN released may react with oxygen to generate H2O2 in the acidic microenvironment, and subsequently transform H2O2 to intracellular hydroxyl radicals, inducing enhanced cell-killing effect. By implanting the composite fibres locally at the tumor site of mice, promoted anticancer efficacy was observed with comparison of the intratumoral-injected FeMSN nanoparticles. This study suggests that FeMSN@PG composite fibres can serve as a potential localized PDT platform for effective antitumor purposes, which may spark a series of follow-on investigations for localized cancer therapeutic technology.

Type: Article
Title: Implantable composite fibres with Self-supplied H2O2 for localized chemodynamic therapy
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.cej.2020.124211
Publisher version: https://doi.org/10.1016/j.cej.2020.124211
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Chemodynamic therapy, FeMSN, Localized drug delivery system, Self-supplied H2O2, Cancer therapy
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Mechanical Engineering
URI: https://discovery.ucl.ac.uk/id/eprint/10092302
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