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Multiscale dual-mode photoacoustic imaging with a Fabry-Pérot scanner

Brand, Sophie; (2020) Multiscale dual-mode photoacoustic imaging with a Fabry-Pérot scanner. Doctoral thesis (Ph.D), UCL (University College London). Green open access

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Abstract

This thesis proposes the design of a dual-mode photoacoustic tomography and optical-resolution photoacoustic microscopy scanner. Photoacoustic tomography can visualise larger blood vessels in the skin with a penetration depth of up to 1 cm. Optical-resolution photoacoustic microscopy can image the microvasculature at a capillary level in the skin with a penetration depth of up to 1 mm. A combination of both modes will result in images that have both, larger penetration depths from the tomography mode and high resolution in superficial depths from the microscopy mode. The integration of both modes in one scanner is straightforward if the scanner is based on the Fabry-Perot ultrasound sensor since it is transparent to the excitation wavelength image. A dual-mode Fabry-Perot based scanner has been reported before but modifications are needed for successful in vivo imaging. Dual-mode piezoelectric detector based scanners have not been proposed so far. This thesis describes the work that was undertaken to improve the performance of both scanners and achieve dual-mode photoacoustic tomography (PAT) and optical-resolution microscopy (OR-PAM). A novel laser-scanning optical-resolution photoacoustic microscopy system (LSOR-PAM) was developed and integrated into the same scanner. The system performance was assessed individually for all setups. PAT, OR-PAM and LSOR-PAM images were taken successfully from various phantoms and a mouse ear (ex vivo). A large part of the work that was undertaken in preparation of dual-mode image acquisition was the design of a novel Fabry-Perot sensor. The original design of the mirrors that form the Fabry-Perot cavity has been analysed in detail. The effect of changes in the mirror design and the effect of uncertainties arising from the manufacturing process of the mirrors were analysed. Based on the results of this analysis a new design for the mirrors was proposed. The new sensor is transparent at excitation wavelengths for both PAT and OR-PAM/LSOR-PAM.

Type: Thesis (Doctoral)
Qualification: Ph.D
Title: Multiscale dual-mode photoacoustic imaging with a Fabry-Pérot scanner
Event: UCL (University College London)
Open access status: An open access version is available from UCL Discovery
Language: English
Additional information: Copyright © The Author 2020. Original content in this thesis is licensed under the terms of the Creative Commons Attribution 4.0 International (CC BY 4.0) Licence (https://creativecommons.org/licenses/by/4.0/). Any third-party copyright material present remains the property of its respective owner(s) and is licensed under its existing terms. Access may initially be restricted at the author’s request.
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng
URI: https://discovery.ucl.ac.uk/id/eprint/10092230
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