UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Implementation of routine interferon-gamma release assay testing in a South London HIV cohort

Sandhu, P; Taylor, C; Miller, RF; Post, FA; (2020) Implementation of routine interferon-gamma release assay testing in a South London HIV cohort. International Journal of STD & AIDS , 31 (3) pp. 264-267. 10.1177/0956462419893536. Green open access

[img]
Preview
Text
Miller_IJSA-19-323Revision (25.10.2019) CLEAN.pdf - Accepted version

Download (708kB) | Preview

Abstract

Human immunodeficiency virus (HIV) infection is a major risk factor for the development of tuberculosis (TB). Although guidelines recommend that people with HIV from high TB incidence countries and those with risk factors are screened for latent TB infection (LTBI) using interferon-gamma release assays (IGRAs), this has not been widely implemented in the UK. We introduced universal LTBI screening using IGRAs at nurse-led induction clinics for patients newly presenting, transferring or re-presenting for HIV care and conducted a prospective audit from 1 January 2018 to 30 June 2019 to identify operational challenges as well as opportunities for TB prevention. Of the 223 patients, 17 had active or previously treated TB. Of the remaining 206 individuals who were eligible for IGRA testing, 78 (38%) were not tested due to logistical issues, failure to request the test or no induction visit taking place. Of the 128 (62%) individuals who were tested for LTBI, 3 (2.3%) had a positive IGRA, 4 (3.1%) an indeterminate result and 121 (94.5%) a negative result. All seven with positive/indeterminate tests were of African/Caribbean background, had CD4 cell counts >200 cells/mm3 and HIV RNA <400 copies/ml. Our audit suggests that universal LTBI screening was logistically challenging and provided few opportunities for TB prevention.

Type: Article
Title: Implementation of routine interferon-gamma release assay testing in a South London HIV cohort
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1177/0956462419893536
Publisher version: http://dx.doi.org/10.1177/0956462419893536
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: HIV, interferon-gamma release assay, prevention, prophylaxis, screening, tuberculosis
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute for Global Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute for Global Health > Infection and Population Health
URI: https://discovery.ucl.ac.uk/id/eprint/10091857
Downloads since deposit
10Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item