Lefler, Y;
Amsalem, O;
Vrieler, N;
Segev, I;
Yarom, Y;
(2020)
Using subthreshold events to characterize the functional architecture of the electrically coupled inferior olive network.
eLife
, 9
, Article e43560. 10.7554/eLife.43560.
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Abstract
The electrical connectivity in the inferior olive (IO) nucleus plays an important role in generating well-timed spiking activity. Here we combined electrophysiological and computational approaches to assess the functional organization of the IO nucleus in mice. Spontaneous fast and slow subthreshold events were commonly encountered during in vitro recordings. We show that whereas the fast events represent intrinsic regenerative activity, the slow events reflect the electrical connectivity between neurons ('spikelets'). Recordings from cell pairs revealed the synchronized occurrence of distinct groups of spikelets; their rate and distribution enabled an accurate estimation of the number of connected cells and is suggestive of a clustered organization. This study thus provides a new perspective on the functional and structural organization of the olivary nucleus and a novel experimental and theoretical approach to study electrically coupled networks.
| Type: | Article |
|---|---|
| Title: | Using subthreshold events to characterize the functional architecture of the electrically coupled inferior olive network |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.7554/eLife.43560 |
| Publisher version: | https://doi.org/10.7554/eLife.43560 |
| Language: | English |
| Additional information: | This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
| Keywords: | Computational model, electrically coupled networks, inferior olive, mouse, neuroscience, spikelets |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > The Sainsbury Wellcome Centre |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10091799 |
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