Allahham, N;
Fina, F;
Marcuta, C;
Kraschew, L;
Mohr, W;
Gaisford, S;
Basit, AW;
(2020)
Selective Laser Sintering 3D Printing of Orally Disintegrating Printlets Containing Ondansetron.
Pharmaceutics
, 12
(2)
, Article 110. 10.3390/pharmaceutics12020110.
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Abstract
The aim of this work was to explore the feasibility of using selective laser sintering (SLS) 3D printing (3DP) to fabricate orodispersable printlets (ODPs) containing ondansetron. Ondansetron was first incorporated into drug-cyclodextrin complexes and then combined with the filler mannitol. Two 3D printed formulations with different levels of mannitol were prepared and tested, and a commercial ondansetron orally disintegrating tablet (ODT) product (Vonau® Flash) was also investigated for comparison. Both 3D printed formulations disintegrated at ~15 s and released more than 90% of the drug within 5 min independent of the mannitol content; these results were comparable to those obtained with the commercial product. This work demonstrates the potential of SLS 3DP to fabricate orodispersible printlets with characteristics similar to a commercial ODT, but with the added benefit of using a manufacturing technology able to prepare medicines individualized to the patient.
| Type: | Article |
|---|---|
| Title: | Selective Laser Sintering 3D Printing of Orally Disintegrating Printlets Containing Ondansetron |
| Location: | Switzerland |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3390/pharmaceutics12020110 |
| Publisher version: | https://doi.org/10.3390/pharmaceutics12020110 |
| Language: | English |
| Additional information: | This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
| Keywords: | 3D printed drug products, additive manufacturing, orally disintegrating printlets (ODPs), orally disintegrating tablets (ODTs), personalized medicines, printing pharmaceuticals, rapid prototyping, taste masking, three-dimensional printing |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharmaceutics |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10091190 |
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