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Plasma NRTI concentration and their associations with liver and renal parameters in people living with HIV

Wang, X; Boffito, M; Dickinson, L; Bagkeris, E; Khoo, S; Post, FA; Vera, J; ... POPPY Study, .; + view all (2020) Plasma NRTI concentration and their associations with liver and renal parameters in people living with HIV. AIDS , 34 (5) pp. 790-793. 10.1097/QAD.0000000000002479.

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Abstract

Associations between markers of liver and renal dysfunction and NRTI plasma exposure are ill-defined. As part of a large cohort study (POPPY), we analysed associations between ALT and eGFR results in people living with HIV on tenofovir (TFV) disoproxil fumarate (TDF), emtricitabine (FTC), abacavir (ABC) and lamivudine (3TC). While we found no associations between NRTI concentrations and ALT, lower eGFR values were associated with greater TFV, FTC and 3TC exposure, whereas ABC showed no associations.

Type: Article
Title: Plasma NRTI concentration and their associations with liver and renal parameters in people living with HIV
Location: England
DOI: 10.1097/QAD.0000000000002479
Publisher version: https://doi.org/10.1097/QAD.0000000000002479
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute for Global Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute for Global Health > Infection and Population Health
URI: https://discovery.ucl.ac.uk/id/eprint/10090834
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