Suárez-Pinilla, M;
Benavente Fernández, L;
Calleja Puerta, S;
(2013)
A longitudinal retrospective study on intracranial arterial pulsatility index: its evolution in ten years' time and how it relates to the occurrence of cerebral and systemic ischemic disease.
Presented at: 18th Meeting of the European Society of Neurosonology and Cerebral Hemodynamics, Porto, Portugal.
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Abstract
BACKGROUND AND AIMS: Intracranial arterial pulsatility index (PI) has been related to old age, hypertension, diabetes and small vessel disease. However, the cross- sectional design of most studies prevents a proper assessment of causality and evolution. We sought to explore how this index changes through time, which conditions affect this evolution and whether or not it can predict the occurrence of future ischemic events. METHODS: Between the years 2001-2006, 1288 patients underwent a transcranial Doppler evaluation in the Department of Neurology of the Hospital Universitario Central de Asturias. PI values for the middle cerebral and basilar arteries were systematically annotated. After exclusion of deceased patients and significant large artery stenoses, 89 patients were recruited for a re-evaluation in 2012. Afterwards, the sample was expanded up to 150 patients, with 61 randomly selected patients –either alive or deceased- who did not undergo a second exploration. Both groups had their clinical files reviewed, with special attention to vascular risk factors and brain or coronary ischemic events. RESULTS AND DISCUSSION: Our results pointed to the following conclusions: • Intracranial arterial PI works as a dynamic measure of both cerebral and systemic vascular disease. • Age is the main factor influencing PI value and variation, but, within a certain age group, PI is able to point subjects at higher long-term risk of future ischemic events. • Basilar artery PI seems to be a better predictor of future cerebral and coronary ischemic disease than middle cerebral artery PI.
| Type: | Poster |
|---|---|
| Title: | A longitudinal retrospective study on intracranial arterial pulsatility index: its evolution in ten years' time and how it relates to the occurrence of cerebral and systemic ischemic disease |
| Event: | 18th Meeting of the European Society of Neurosonology and Cerebral Hemodynamics |
| Location: | Porto, Portugal |
| Dates: | 24 - 27 May 2013 |
| Open access status: | An open access version is available from UCL Discovery |
| Publisher version: | https://esnch.org/esnch-conferences/ |
| Language: | English |
| Keywords: | cerebrovascular disease, neurosonology, transcranial Doppler, pulsatility index, longitudinal study, vascular risk factors |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10090190 |
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