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Pharmacological agents to reduce readmissions in bipolar disorder

Rogers, J; Taylor, MJ; (2017) Pharmacological agents to reduce readmissions in bipolar disorder. Journal of Psychopharmacology , 31 (3) pp. 387-388. 10.1177/0269881116672099. Green open access

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Abstract

It is well recognized that medications have an important role to play in preventing relapse in bipolar disorder. The impact these treatments have on rates of admission to hospital in particular has been less well studied. We combined data on hospitalization from 11 randomized controlled trials in a network meta-analysis. We found that the published evidence demonstrates significant reductions in admission rates compared to placebo from lithium (risk ratio (RR) 0.44, 95% confidence interval (CI) 0.32–0.59), valproate (RR 0.50, 95% CI 0.28–0.90), a combination of lithium and valproate (RR 0.50, 95% CI 0.28–0.90), carbamazepine (RR 0.46, 95% CI 0.29–0.73) and olanzapine (RR 0.27, 95% CI 0.16–0.43). The evidence base contributing to these estimates remains fairly small, leading to broad confidence intervals for estimates of effect. More precise estimates could be obtained if unpublished outcomes data from other trials in this area became available. Several pharmacological treatments appear to be effective at reducing the need for hospital admission in people with bipolar disorder.

Type: Article
Title: Pharmacological agents to reduce readmissions in bipolar disorder
Open access status: An open access version is available from UCL Discovery
DOI: 10.1177/0269881116672099
Publisher version: https://doi.org/10.1177/0269881116672099
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Bipolar disorder, hospitalization, antimanic agents, antipsychotic agents, meta-analysis
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Division of Psychiatry
URI: https://discovery.ucl.ac.uk/id/eprint/10089409
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