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Alcohol septal ablation for hypertrophic obstructive cardiomyopathy: a contemporary reappraisal

Pelliccia, F; Niccoli, G; Gragnano, F; Limongelli, G; Moscarella, E; Ando, G; Esposito, A; ... Calabro, P; + view all (2019) Alcohol septal ablation for hypertrophic obstructive cardiomyopathy: a contemporary reappraisal. Eurointervention , 15 (5) pp. 411-417. 10.4244/EIJ-D-18-00959.

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Abstract

Percutaneous alcohol septal ablation (ASA) is an effective and minimally invasive therapeutic strategy to resolve left ventricular outflow tract obstruction (LVOTO) in patients with hypertrophic cardiomyopathy who remain symptomatic on maximally tolerated medical therapy. First performed by Sigwart in 1994, the procedure consists in determining an iatrogenic infarction of the basal interventricular septum to reduce LVOTO and alleviate symptoms. Since its first description, numerous studies have demonstrated its efficacy and safety, proposing ASA as a valid and attractive alternative to surgical septal myectomy. The success rate of the intervention is profoundly affected by patient selection and centre experience. In this review, we sought to summarise current evidence on ASA, describing the procedure and proposing a cardiomyopathy team-based approach to resolve clinical disputes in clinical practice.

Type: Article
Title: Alcohol septal ablation for hypertrophic obstructive cardiomyopathy: a contemporary reappraisal
DOI: 10.4244/EIJ-D-18-00959
Publisher version: http://doi.org/10.4244/EIJ-D-18-00959
Language: English
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science > Clinical Science
URI: https://discovery.ucl.ac.uk/id/eprint/10088870
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