Bainbridge, A;
Bray, T;
Sengupta, R;
Hall-Craggs, M;
(2020)
Practical Approaches to Bone Marrow Fat Fraction Quantification Across Magnetic Resonance Imaging Platforms.
Journal of Magnetic Resonance Imaging
, 52
(1)
pp. 298-306.
10.1002/jmri.27039.
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Abstract
Background: Proton density fat fraction (PDFF) measurements can objectively identify bone marrow oedema and fat metaplasia in spondyloarthritis and may be valuable for the quantification of inflammation in multi-center clinical trials and routine practice. However, many centers do not have access to specialist methods for PDFF measurement. This is a barrier to implementation. Purpose/Hypothesis: To determine the agreement between fat fraction (FF) measurements derived from (1) basic vendor-supplied sequences (2) basic sequences with offline correction and (3) specialist vendor-supplied methods. Study type: Prospective. Population/subjects/phantom/specimen/animal model: Two substudies with ten and five healthy volunteers. Field strength/sequence: Site A: mDixon Quant (Philips 3T Ingenia); Site B: IDEAL and FLEX (GE 1.5T Optima MR450W); Site C: DIXON, with additional 5-echo gradient echo acquisition for offline correction (Siemens 3T Skyra); Site D: DIXON, with additional VIBE acqusitions for offline correction (Siemens 1.5T Avanto). The specialist method at site A was used as a standard to compare to the basic methods at sites B, C and D. Assessment: Regions of interest were placed on areas of subchondral bone on FF maps from the various methods in each volunteer. Statistical tests: Relationships between FF measurements from the various sites and Dixon methods were assessed using Bland-Altman analysis and linear regression. Results: Basic methods consisting of IDEAL, LAVA FLEX and DIXON produced FF values that were linearly related to reference FF values (P<0.0001), but produced mean biases of up to 10%. Offline correction produced a significant reduction in bias in both substudies (P<0.001). Data Conclusion: FF measurements derived using basic vendor-supplied methods are strongly linearly related to those derived using specialist methods but produce a bias of up to 10%. A simple offline correction that is accessible even when the scanner has only basic sequence options can significantly reduce bias.
| Type: | Article |
|---|---|
| Title: | Practical Approaches to Bone Marrow Fat Fraction Quantification Across Magnetic Resonance Imaging Platforms |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1002/jmri.27039 |
| Publisher version: | https://doi.org/10.1002/jmri.27039 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Spondyloarthritis, Chemical shift imaging, Inflammation, Imaging biomarker |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Department of Imaging |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10088863 |
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