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Practical Approaches to Bone Marrow Fat Fraction Quantification Across Magnetic Resonance Imaging Platforms

Bainbridge, A; Bray, T; Sengupta, R; Hall-Craggs, M; (2020) Practical Approaches to Bone Marrow Fat Fraction Quantification Across Magnetic Resonance Imaging Platforms. Journal of Magnetic Resonance Imaging , 52 (1) pp. 298-306. 10.1002/jmri.27039. Green open access

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Abstract

Background: Proton density fat fraction (PDFF) measurements can objectively identify bone marrow oedema and fat metaplasia in spondyloarthritis and may be valuable for the quantification of inflammation in multi-center clinical trials and routine practice. However, many centers do not have access to specialist methods for PDFF measurement. This is a barrier to implementation. Purpose/Hypothesis: To determine the agreement between fat fraction (FF) measurements derived from (1) basic vendor-supplied sequences (2) basic sequences with offline correction and (3) specialist vendor-supplied methods. Study type: Prospective. Population/subjects/phantom/specimen/animal model: Two substudies with ten and five healthy volunteers. Field strength/sequence: Site A: mDixon Quant (Philips 3T Ingenia); Site B: IDEAL and FLEX (GE 1.5T Optima MR450W); Site C: DIXON, with additional 5-echo gradient echo acquisition for offline correction (Siemens 3T Skyra); Site D: DIXON, with additional VIBE acqusitions for offline correction (Siemens 1.5T Avanto). The specialist method at site A was used as a standard to compare to the basic methods at sites B, C and D. Assessment: Regions of interest were placed on areas of subchondral bone on FF maps from the various methods in each volunteer. Statistical tests: Relationships between FF measurements from the various sites and Dixon methods were assessed using Bland-Altman analysis and linear regression. Results: Basic methods consisting of IDEAL, LAVA FLEX and DIXON produced FF values that were linearly related to reference FF values (P<0.0001), but produced mean biases of up to 10%. Offline correction produced a significant reduction in bias in both substudies (P<0.001). Data Conclusion: FF measurements derived using basic vendor-supplied methods are strongly linearly related to those derived using specialist methods but produce a bias of up to 10%. A simple offline correction that is accessible even when the scanner has only basic sequence options can significantly reduce bias.

Type: Article
Title: Practical Approaches to Bone Marrow Fat Fraction Quantification Across Magnetic Resonance Imaging Platforms
Open access status: An open access version is available from UCL Discovery
DOI: 10.1002/jmri.27039
Publisher version: https://doi.org/10.1002/jmri.27039
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Spondyloarthritis, Chemical shift imaging, Inflammation, Imaging biomarker
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Department of Imaging
URI: https://discovery.ucl.ac.uk/id/eprint/10088863
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