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Dopaminergic and Prefrontal Basis of Learning from Sensory Confidence and Reward Value

Lak, A; Okun, M; Moss, MM; Gurnani, H; Farrell, K; Wells, MJ; Reddy, CB; ... Carandini, M; + view all (2019) Dopaminergic and Prefrontal Basis of Learning from Sensory Confidence and Reward Value. Neuron , 105 (4) pp. 593-595. 10.1016/j.neuron.2019.11.018. Green open access

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Abstract

Deciding between stimuli requires combining their learned value with one’s sensory confidence. We trained mice in a visual task that probes this combination. Mouse choices reflected not only present confidence and past rewards but also past confidence. Their behavior conformed to a model that combines signal detection with reinforcement learning. In the model, the predicted value of the chosen option is the product of sensory confidence and learned value. We found precise correlates of this variable in the pre-outcome activity of midbrain dopamine neurons and of medial prefrontal cortical neurons. However, only the latter played a causal role: inactivating medial prefrontal cortex before outcome strengthened learning from the outcome. Dopamine neurons played a causal role only after outcome, when they encoded reward prediction errors graded by confidence, influencing subsequent choices. These results reveal neural signals that combine reward value with sensory confidence and guide subsequent learning.

Type: Article
Title: Dopaminergic and Prefrontal Basis of Learning from Sensory Confidence and Reward Value
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.neuron.2019.11.018
Publisher version: https://doi.org/10.1016/j.neuron.2019.11.018
Language: English
Additional information: This version is the version of record published under a Creative Commons license (https://creativecommons.org/licenses/by/4.0/)
Keywords: Calcium imaging, Decision confidence, Electrophysiology, Mice, Optogenetics, Psychophysics, Reinforcement learning
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Department of Neuromuscular Diseases
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
URI: https://discovery.ucl.ac.uk/id/eprint/10088446
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