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Mimicking the Ice Recrystallization Activity of Biological Antifreezes. When is a New Polymer “Active”?

Biggs, CI; Stubbs, C; Graham, B; Fayter, AER; Hasan, M; Gibson, MI; (2019) Mimicking the Ice Recrystallization Activity of Biological Antifreezes. When is a New Polymer “Active”? Macromolecular Bioscience , 19 (7) , Article 1900082. 10.1002/mabi.201900082. Green open access

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Abstract

Abstract Antifreeze proteins and ice‐binding proteins have been discovered in a diverse range of extremophiles and have the ability to modulate the growth and formation of ice crystals. Considering the importance of cryoscience across transport, biomedicine, and climate science, there is significant interest in developing synthetic macromolecular mimics of antifreeze proteins, in particular to reproduce their property of ice recrystallization inhibition (IRI). This activity is a continuum rather than an “on/off” property and there may be multiple molecular mechanisms which give rise to differences in this observable property; the limiting concentrations for ice growth vary by more than a thousand between an antifreeze glycoprotein and poly(vinyl alcohol), for example. The aim of this article is to provide a concise comparison of a range of natural and synthetic materials that are known to have IRI, thus providing a guide to see if a new synthetic mimic is active or not, including emerging materials which are comparatively weak compared to antifreeze proteins, but may have technological importance. The link between activity and the mechanisms involving either ice binding or amphiphilicity is discussed and known materials assigned into classes based on this.

Type: Article
Title: Mimicking the Ice Recrystallization Activity of Biological Antifreezes. When is a New Polymer “Active”?
Open access status: An open access version is available from UCL Discovery
DOI: 10.1002/mabi.201900082
Publisher version: https://doi.org/10.1002/mabi.201900082
Language: English
Additional information: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0/
Keywords: antifreeze proteins, biomaterials, cryopreservation, ice recrystallization, polymers
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Wolfson Inst for Biomedical Research
URI: https://discovery.ucl.ac.uk/id/eprint/10087908
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