UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Ten-Year Reflections on the Neurophysiological Abnormalities of Focal Dystonias in Humans

Conte, A; Rocchi, L; Latorre, A; Belvisi, D; Rothwell, JC; Berardelli, A; (2019) Ten-Year Reflections on the Neurophysiological Abnormalities of Focal Dystonias in Humans. Movement Disorders 10.1002/mds.27859. (In press).

[img] Text
Rocchi Conte_et_al._Mov_disord_review 19 8.pdf - Accepted version
Access restricted to UCL open access staff

Download (643kB)

Abstract

The physiological landscape of dystonia has changed considerably over the past 10 years. Initial ideas that dystonic motor symptoms could be explained by a combination of loss of inhibition and increased plasticity, together with subtle deficits in sensory processing, have been questioned, whereas the possible role of the cerebellum has risen in importance. In addition, it has been recognized that symptoms affect more than just the motor and sensory systems and encompass independent cognitive and psychological changes. Finally, it has become clear that, despite similarities in symptoms, there may be pathophysiological differences between idiopathic, inherited, and acquired forms of dystonia. In other words, progress in the pathophysiology of dystonia has followed the usual pattern from an initial phase in which core deficits are readily explained by highly simplified models to a realization that within a highly interconnected network, effects are more nuanced with widespread changes that might either compensate or contribute to the clinical symptoms to different degrees in different individuals.

Type: Article
Title: Ten-Year Reflections on the Neurophysiological Abnormalities of Focal Dystonias in Humans
Location: United States
DOI: 10.1002/mds.27859
Publisher version: https://doi.org/10.1002/mds.27859
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Dystonia, inhibition, pathophysiology, plasticity, sensory processing
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences
URI: https://discovery.ucl.ac.uk/id/eprint/10086038
Downloads since deposit
1Download
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item