UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Assessing the Interocular Symmetry of Foveal Outer Nuclear Layer Thickness in Achromatopsia

Mastey, RR; Gaffney, M; Litts, KM; Langlo, CS; Patterson, EJ; Strampe, MR; Kalitzeos, A; ... Carroll, J; + view all (2019) Assessing the Interocular Symmetry of Foveal Outer Nuclear Layer Thickness in Achromatopsia. Translational Vision Science & Technology , 8 (5) , Article 21. 10.1167/tvst.8.5.21. Green open access

[thumbnail of i2164-2591-8-5-21.pdf]
Preview
Text
i2164-2591-8-5-21.pdf - Published Version

Download (767kB) | Preview

Abstract

Purpose: We examine the interocular symmetry of foveal outer nuclear layer (ONL) thickness measurements in subjects with achromatopsia (ACHM). Methods: Images from 76 subjects with CNGA3- or CNGB3-associated ACHM and 42 control subjects were included in the study. Line or volume scans through the fovea of each eye were acquired using optical coherence tomography (OCT). Image quality was assessed for each image included in the analysis using a previously-described maximum tissue contrast index (mTCI) metric. Three foveal ONL thickness measurements were made by a single observer and interocular symmetry was assessed using the average of the three measurements for each eye. Results: Mean (± standard deviation) foveal ONL thickness for subjects with ACHM was 79.7 ± 18.3 μm (right eye) and 79.2 ± 18.7 μm (left eye) compared to 112.9 ± 15.2 (right eye) and 112.1 ± 13.9 μm (left eye) for controls. Foveal ONL thickness did not differ between eyes for ACHM (P = 0.636) or control subjects (P = 0.434). No significant relationship between mTCI and observer repeatability was observed for either control (P = 0.140) or ACHM (P = 0.351) images. Conclusions: While foveal ONL thickness is reduced in ACHM compared to controls, the high interocular symmetry indicates that contralateral ONL measurements could be used as a negative control in early-phase monocular treatment trials. Translational Relevance: Foveal ONL thickness can be measured using OCT images over a wide range of image quality. The interocular symmetry of foveal ONL thickness in ACHM and control populations supports the use of the non-study eye as a control for clinical trial purposes.

Type: Article
Title: Assessing the Interocular Symmetry of Foveal Outer Nuclear Layer Thickness in Achromatopsia
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1167/tvst.8.5.21
Publisher version: https://doi.org/10.1167/tvst.8.5.21
Language: English
Additional information: Copyright © 2019 The Authors. This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (http://creativecommons.org/licenses/by-nc-nd/4.0).
Keywords: achromatopsia, optical coherence tomography, outer nuclear layer
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology
URI: https://discovery.ucl.ac.uk/id/eprint/10083497
Downloads since deposit
35Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item